iPTMnet Report for O00422 (SAP18)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00422 / SAP18_HUMAN
Protein Name Histone deacetylase complex subunit SAP18
Gene Name Name: SAP18
ORFNames:GIG38;
Organism Homo sapiens (Human)

PRO ID PR:O00422
DAG View
PRO Name histone deacetylase complex subunit SAP18 (human)
Definition A histone deacetylase complex subunit SAP18 that is encoded in the genome of human.
Short Label hSAP18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00422 (SAP18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S5 O-Glycosylation GlyGen 33465208
T8 O-Glycosylation GlyGen 30444036, 28510447, 33465208, ...34019948
T8 Phosphorylation PhosphoSitePlus
K13 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
R142 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T44 Phosphorylation HPRD 20068230
T54 Phosphorylation HPRD 20068230
T104 Phosphorylation HPRD 18491316
Y120 Phosphorylation HPRD 18491316


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 L5 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K13 E13 Biomuta DOID:3571 / liver cancer [ cosmic ]
K13 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K74 N74 Biomuta DOID:363 / uterine cancer [ icgc ]
S119 Y119 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R142 Q142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]