iPTMnet Report for O00411 (POLRMT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00411 / RPOM_HUMAN
Protein Name DNA-directed RNA polymerase, mitochondrial precursor
Gene Name Name: POLRMT
Organism Homo sapiens (Human)

PRO ID PR:O00411
DAG View
PRO Name DNA-directed RNA polymerase, mitochondrial (human)
Definition A DNA-directed RNA polymerase, mitochondrial that is encoded in the genome of human.
Short Label hPOLRMT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00411 (POLRMT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R8 Methylation PhosphoSitePlus
K28 Methylation PhosphoSitePlus
S77 Phosphorylation HPRD   PhosphoSitePlus 19691289
T115 Phosphorylation HPRD 19007248
S150 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
Y386 Phosphorylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
T436 Phosphorylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
C547 Methylation IEDB 31844290
C765 Methylation IEDB 31844290
T993 Phosphorylation PhosphoSitePlus
Y999 Phosphorylation PhosphoSitePlus
Y1004 Phosphorylation PhosphoSitePlus
K1197 Ubiquitination PhosphoSitePlus
K1205 Ubiquitination PhosphoSitePlus
K1213 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K28 R28 Biomuta DOID:4159 / skin cancer [ cosmic ]
S150 N150 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y386 C386 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1004 C1004 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y1004 F1004 Biomuta DOID:3571 / liver cancer [ cosmic ]