Protein Information

Cytoscape View


UniProt AC / UniProt ID O00410 / IPO5_HUMAN
Protein Name Importin-5
Gene Name Name: IPO5
Synonyms:KPNB3,RANBP5;
Organism Homo sapiens (Human)

PRO ID PR:O00410
DAG View
PRO Name importin-5 (human)
Definition An importin-5 that is encoded in the genome of human.
Short Label hIPO5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00410 (IPO5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
S20 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
Y78 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
Y530 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
T633 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S635 Phosphorylation PhosphoSitePlus
T645 Phosphorylation PhosphoSitePlus
S652 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K671 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
T680 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
Y699 Phosphorylation PhosphoSitePlus
T700 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
K800 Acetylation PhosphoSitePlus
K800 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
R811 Methylation PhosphoSitePlus
Y820 Phosphorylation PhosphoSitePlus
S827 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...18669648, 19690332, 20068231
K963 Ubiquitination PhosphoSitePlus
C972 S-Nitrosylation dbSNO 2212679, 22126794
K978 Ubiquitination PhosphoSitePlus
S1040 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:3571 / liver cancer [ icgc ]
Y78 S78 Biomuta DOID:263 / kidney cancer [ tcga ]
S239 Y239 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T633 A633 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S635 L635 Biomuta DOID:4362 / cervical cancer [ tcga ]
S652 G652 Biomuta DOID:1909 / melanoma [ cosmic ]
T700 I700 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R811 * Biomuta DOID:363 / uterine cancer [ tcga ]