iPTMnet Report for O00408 (PDE2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00408 / PDE2A_HUMAN
Protein Name cGMP-dependent 3',5'-cyclic phosphodiesterase
Gene Name Name: PDE2A
Organism Homo sapiens (Human)

PRO ID PR:O00408
DAG View
PRO Name cGMP-dependent 3',5'-cyclic phosphodiesterase (human)
Definition A cGMP-dependent 3',5'-cyclic phosphodiesterase that is encoded in the genome of human.
Short Label hPDE2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00408 (PDE2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 19632989, 20213681
S13 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
Y754 Phosphorylation PhosphoSitePlus
Y854 Phosphorylation PhosphoSitePlus
Y871 Phosphorylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
Y920 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S125 L125 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K584 N584 Biomuta DOID:363 / uterine cancer [ icgc ]
S912 L912 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]