Protein Information

Cytoscape View


UniProt AC / UniProt ID O00401 / WASL_HUMAN
Protein Name Neural Wiskott-Aldrich syndrome protein
Gene Name Name: WASL
Organism Homo sapiens (Human)

PRO ID PR:O00401
DAG View
PRO Name neural Wiskott-Aldrich syndrome protein (human)
Definition A neural Wiskott-Aldrich syndrome protein that is encoded in the genome of human.
Short Label hWASL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00401 (WASL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895
T15 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
Y175 Phosphorylation P00519 (ABL1) HPRD   neXtProt   PhosphoSitePlus 16199863
S183 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
T199 Phosphorylation Q13627 (DYRK1A) neXtProt 22250195
T205 Phosphorylation Q13627 (DYRK1A) neXtProt   PhosphoSitePlus 22250195
S242 Phosphorylation UniProt 16257963
K253 Ubiquitination PhosphoSitePlus
Y256 Phosphorylation P42684 (ABL2) , P00519 (ABL1) , Q05397 (PTK2) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 19901323, 14676198, 16257963, ...20146487, 19664994, 18452278, 18083107, 16199863, 23212915, 17389395, 20940394, 18707149, 22886502, 25277185, 19415658, 20068231
K261 Ubiquitination PhosphoSitePlus
T262 Phosphorylation Q13627 (DYRK1A) neXtProt 22250195
R274 Methylation PhosphoSitePlus
R284 Methylation PhosphoSitePlus
R305 Methylation PhosphoSitePlus
R307 Methylation PhosphoSitePlus   UniProt 24129315
R329 Methylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
S484 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18452278, 19651622, ...18669648, 29100370, 20068231
S485 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18452278, 19651622, ...18669648, 20068231, 29100370


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049674 (hWASL/Phos:1) pY256 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00401 (WASL) Y256 P61160 (ACTR2) unknown eFIP 23212915
Phosphorylation Q14247 (CTTN) S418 O00401 (WASL) unknown eFIP 22952966


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 R2 Biomuta DOID:1115 / sarcoma [ tcga ]
S58 L58 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T135 I135 Biomuta DOID:2596 / larynx cancer [ cosmic ]
T205 K205 Biomuta DOID:3571 / liver cancer [ icgc ]
S242 L242 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T262 A262 Biomuta DOID:363 / uterine cancer [ cosmic ]
R274 M274 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T460 K460 Biomuta DOID:363 / uterine cancer [ cosmic ]
T464 N464 Biomuta DOID:3571 / liver cancer [ icgc ]