iPTMnet Report for O00330 (PDHX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00330 / ODPX_HUMAN
Protein Name Pyruvate dehydrogenase protein X component, mitochondrial precursor
Gene Name Name: PDHX
Synonyms:PDX1;
Organism Homo sapiens (Human)

PRO ID PR:O00330
DAG View
PRO Name pyruvate dehydrogenase protein X component, mitochondrial (human)
Definition A pyruvate dehydrogenase protein X component, mitochondrial that is encoded in the genome of human.
Short Label hPDHX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00330 (PDHX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y16 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
K194 Acetylation PhosphoSitePlus   UniProt 19608861
S196 Phosphorylation PhosphoSitePlus   UniProt 24275569
S200 Phosphorylation PhosphoSitePlus
R208 Methylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
T274 O-Glycosylation GlyGen 31373491
K314 Ubiquitination PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S392 Phosphorylation IEDB 35494241
K394 Ubiquitination PhosphoSitePlus
K460 Acetylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K488 Acetylation PhosphoSitePlus
K491 Acetylation PhosphoSitePlus
K491 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S162 Phosphorylation HPRD 18491316
S168 Phosphorylation HPRD 18491316
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
T15 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y16 S16 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S65 F65 Biomuta DOID:1612 / breast cancer [ cosmic ]
T101 A101 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S162 L162 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S168 F168 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R208 W208 Biomuta DOID:4159 / skin cancer [ cosmic ]
R208 G208 Biomuta DOID:3571 / liver cancer [ cosmic ]
S392 C392 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K491 E491 Biomuta DOID:4159 / skin cancer [ cosmic ]