Protein Information

Cytoscape View


UniProt AC / UniProt ID O00329 / PK3CD_HUMAN
Protein Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Gene Name Name: PIK3CD
Organism Homo sapiens (Human)

PRO ID PR:O00329
DAG View
PRO Name phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (human)
Definition A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform that is encoded in the genome of human.
Short Label hPIK3CD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00329 (PIK3CD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K46 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
K449 Ubiquitination PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
Y485 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
S520 Phosphorylation PhosphoSitePlus
Y524 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 19369195, 16497976
K528 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
T935 Phosphorylation PhosphoSitePlus
Y936 Phosphorylation PhosphoSitePlus
S950 O-Glycosylation GlyGen 29351928
K999 Ubiquitination PhosphoSitePlus
K1006 Ubiquitination PhosphoSitePlus
K1013 Ubiquitination PhosphoSitePlus
K1030 Ubiquitination PhosphoSitePlus
S1039 Phosphorylation O00329 (PIK3CD) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 10064595, 23186163, ...9113989
Site PTM Type PTM Enzyme Score Source PMID
S1039 Phosphorylation HPRD 10064595


O00329 (PIK3CD) as PTM Enzyme



Substrate Site Score Source PMID
O00329 (PIK3CD) S1039 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10064595, 9113989


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q08345 (DDR1) Y881 O00329 (PIK3CD) unknown eFIP 22057045


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S406 C406 Biomuta DOID:363 / uterine cancer [ tcga ]
K449 N449 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y485 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S520 A520 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
K684 R684 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K1013 R1013 Biomuta DOID:9256 / colorectal cancer [ tcga ]