iPTMnet Report for O00329 (PIK3CD)
Protein Information
| UniProt AC / UniProt ID | O00329 / PK3CD_HUMAN |
| Protein Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform |
| Gene Name | Name: PIK3CD |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O00329 |
| PRO Name | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (human) |
| Definition | A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform that is encoded in the genome of human. |
| Short Label | hPIK3CD |
| Category | organism-gene |
DAG ViewO00329 (PIK3CD) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K46 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T226 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C257 | Methylation | score1 | IEDB | 31844290 | ||
| S312 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S315 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K372 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S406 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S411 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y440 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16497976 | ||
| K449 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y484 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y485 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16497976 | ||
| S520 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y524 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 18083107, 19369195, 35863698, ... | ||
| K528 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K533 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C590 | Methylation | score1 | IEDB | 31844290 | ||
| C627 | Methylation | score1 | IEDB | 31844290 | ||
| K684 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S690 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K691 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K693 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K841 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K852 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K862 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T935 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y936 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S950 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
| K999 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1006 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1013 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1030 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1039 | Phosphorylation | O00329 (PIK3CD) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 19369195, 10064595, 23186163, ... |
O00329 (PIK3CD) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O00329 (PIK3CD) | S1039 | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 10064595, 9113989 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T226 | I226 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K372 | N372 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S406 | C406 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K449 | N449 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc, tcga ] | |
| Y485 | * | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| S520 | A520 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| C627 | F627 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K684 | R684 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y936 | N936 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K1013 | R1013 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |
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