Protein Information

Cytoscape View

UniProt AC / UniProt ID O00311 / CDC7_HUMAN
Protein Name Cell division cycle 7-related protein kinase
Gene Name Name: CDC7
Organism Homo sapiens (Human)

PRO ID PR:O00311
DAG View
PRO Name cell division cycle 7-related protein kinase (human)
Definition A cell division cycle 7-related protein kinase that is encoded in the genome of human.
Short Label hCDC7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O00311 (CDC7) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
K29 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K36 Sumoylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K59 Sumoylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K179 Sumoylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K235 Sumoylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
K244 Sumoylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K268 Sumoylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K274 Sumoylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
K331 Sumoylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
T376 Phosphorylation P06493 (CDK1) , P24941 (CDK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 27611229, 10846177
T386 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K451 Acetylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus   UniProt 23186163
S509 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
T559 Phosphorylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 18691976
S27 Phosphorylation HPRD 18691976, 19691289
S181 Phosphorylation HPRD 19664994
S302 Phosphorylation HPRD 20058876
T376 Phosphorylation P24941 (CDK2) HPRD 10846177
T503 Phosphorylation HPRD 19413330
S512 Phosphorylation HPRD 19413330

O00311 (CDC7) as PTM Enzyme

Substrate Site Score Source PMID
O75475 (PSIP1) S206 PhosphoSitePlus   Signor 19864417, 7231784
P49736 (MCM2) S4 PhosphoSitePlus 19647517
P49736 (MCM2) S5 PhosphoSitePlus   Signor 19647517
P49736 (MCM2) S7 PhosphoSitePlus 19647517
P49736 (MCM2) S13 Signor 16446360
P49736 (MCM2) S27 PhosphoSitePlus   Signor 16446360, 16899510
P49736 (MCM2) S31 PhosphoSitePlus 18286467
P49736 (MCM2) S40 PhosphoSitePlus   Signor 19647517, 16446360, 24902048, ...18286467, 17062569
P49736 (MCM2) S41 PhosphoSitePlus   Signor 16446360, 24902048, 16899510
P49736 (MCM2) S53 PhosphoSitePlus   Signor 19864417, 19647517, 16446360, ...18286467, 17062569
P49736 (MCM2) S108 PhosphoSitePlus   Signor 19647517, 16446360, 24902048, ...18286467
P49736 (MCM2) S139 PhosphoSitePlus   Signor 18286467, 16446360, 16899510
P49736 (MCM2) S220 PhosphoSitePlus 18286467
Q9HAW4 (CLSPN) S67 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S110 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S260 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S265 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S704 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S721 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S744 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S1129 PhosphoSitePlus 23598722
Q9HAW4 (CLSPN) S1147 PhosphoSitePlus 23598722
Q9NS91 (RAD18) S434 PhosphoSitePlus   Signor 21098111

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P07900 (HSP90AA1) S164 O00311 (CDC7) unknown eFIP 29209046

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S27 P27 Biomuta DOID:363 / uterine cancer [ tcga ]
K179 N179 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S181 N181 Biomuta DOID:363 / uterine cancer [ tcga ]
K191 R191 Biomuta DOID:363 / uterine cancer [ tcga ]
K212 Q212 Biomuta DOID:3070 / malignant glioma [ tcga ]
S297 F297 Biomuta DOID:363 / uterine cancer [ tcga ]
S302 I302 Biomuta DOID:3571 / liver cancer [ icgc ]
K441 R441 Biomuta DOID:3571 / liver cancer [ icgc ]
K492 N492 Biomuta DOID:1612 / breast cancer [ tcga ]