iPTMnet Report for O00308 (WWP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00308 / WWP2_HUMAN
Protein Name NEDD4-like E3 ubiquitin-protein ligase WWP2
Gene Name Name: WWP2
Organism Homo sapiens (Human)

PRO ID PR:O00308
DAG View
PRO Name NEDD4-like E3 ubiquitin-protein ligase WWP2 (human)
Definition A NEDD4-like E3 ubiquitin-protein ligase WWP2 that is encoded in the genome of human.
Short Label hWWP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00308 (WWP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Ubiquitination PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus
C186 S-Nitrosylation dbSNO 24105792
T193 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
S211 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243
K324 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus   RLIMS-P 35331737
Y392 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K473 Sumoylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
Y556 Phosphorylation PhosphoSitePlus
Y587 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 20068231
S211 Phosphorylation HPRD 19007248, 19664995, 16964243
T455 Phosphorylation HPRD 20068231
T467 Phosphorylation HPRD 20068231
T469 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation HPRD 20068231
T28 Phosphorylation HPRD 20068231
T30 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S197 L197 Biomuta DOID:1319 / brain cancer [ icgc ]
Y392 H392 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S487 T487 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S487 F487 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y631 F631 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y631 C631 Biomuta DOID:3571 / liver cancer [ cosmic ]
K820 T820 Biomuta DOID:5041 / esophageal cancer [ cosmic ]