iPTMnet Report for O00305 (CACNB4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00305 / CACB4_HUMAN
Protein Name Voltage-dependent L-type calcium channel subunit beta-4
Gene Name Name: CACNB4
Synonyms:CACNLB4;
Organism Homo sapiens (Human)

PRO ID PR:O00305
DAG View
PRO Name voltage-dependent L-type calcium channel subunit beta-4 (human)
Definition A voltage-dependent L-type calcium channel subunit beta-4 that is encoded in the genome of human.
Short Label hCACNB4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00305 (CACNB4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation PhosphoSitePlus
T99 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S102 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
Y103 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S180 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
Y500 Phosphorylation PhosphoSitePlus
Y512 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R6 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T99 K99 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S180 Y180 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S180 F180 Biomuta DOID:4159 / skin cancer [ cosmic ]
T207 M207 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K276 N276 Biomuta DOID:4362 / cervical cancer [ icgc ]
T421 M421 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S476 F476 Biomuta DOID:4159 / skin cancer [ cosmic ]
S481 I481 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T499 A499 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y512 H512 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y512 C512 Biomuta DOID:10534 / stomach cancer [ cosmic ]