Protein Information

Cytoscape View

UniProt AC / UniProt ID O00303 / EIF3F_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit F
Gene Name Name: EIF3F
Organism Homo sapiens (Human)

PRO ID PR:O00303
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit F (human)
Definition A eukaryotic translation initiation factor 3 subunit F that is encoded in the genome of human.
Short Label hEIF3F
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O00303 (EIF3F) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 17322308
S46 Phosphorylation Q9BWU1 (CDK19) , P21127 (CDK11B) HPRD   IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12446680, 19245811
S105 Phosphorylation PhosphoSitePlus
T119 Phosphorylation Q9BWU1 (CDK19) , P21127 (CDK11B) IntAct   PhosphoSitePlus   Signor 19245811
S142 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y216 Phosphorylation HPRD 20068231
T233 Phosphorylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus   UniProt 19608861
K238 Ubiquitination PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
T255 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
C256 S-Nitrosylation dbSNO 26338901
S258 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17322308, ...20068231
R261 Methylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PRO 19245811
T119 Phosphorylation PRO 19245811


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025800 (hEIF3F/iso:1/Phos:1) pS46,pT119 PRO 19245811

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00303 (EIF3F) T119 P21127 (CDK11B) unknown eFIP 19245811
Phosphorylation P20963 (CD247) Y142 O00303 (EIF3F) unknown eFIP 24502978

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025800 (hEIF3F/iso:1/Phos:1) increased Interaction PR:P55884 (hEIF3B) PRO 19245811

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K154 E154 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ] DOID:1324 / lung cancer [ tcga ]
K161 * Biomuta DOID:5041 / esophageal cancer [ icgc ]
S258 I258 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]