iPTMnet Report for O00291 (HIP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00291 / HIP1_HUMAN
Protein Name Huntingtin-interacting protein 1
Gene Name Name: HIP1
Organism Homo sapiens (Human)

PRO ID PR:O00291
DAG View
PRO Name huntingtin-interacting protein 1 (human)
Definition A huntingtin-interacting protein 1 that is encoded in the genome of human.
Short Label hHIP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00291 (HIP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R3 Methylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
T50 O-Glycosylation GlyGen 30379171, 28510447
K144 Ubiquitination PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus   UniProt 24275569
S455 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
Y1009 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 20058876
S320 Phosphorylation HPRD 20068231
S323 Phosphorylation HPRD 20068231
S1025 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 T9 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S35 T35 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]
T50 M50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S516 L516 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S537 N537 Biomuta DOID:9256 / colorectal cancer [ cosmic ]