iPTMnet Report for O00273 (DFFA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00273 / DFFA_HUMAN
Protein Name DNA fragmentation factor subunit alpha
Gene Name Name: DFFA
Synonyms:DFF1,DFF45;ORFNames:H13;
Organism Homo sapiens (Human)

PRO ID PR:O00273
DAG View
PRO Name DNA fragmentation factor subunit alpha (human)
Definition A DNA fragmentation factor subunit alpha that is encoded in the genome of human.
Short Label hDFFA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00273 (DFFA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
Y27 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
C38 Methylation IEDB 31844290
K45 Ubiquitination PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
C154 Methylation IEDB 31844290
K189 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus   UniProt 23186163
K248 Ubiquitination PhosphoSitePlus
S257 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
R296 Methylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 24275569, 20068231
K324 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation HPRD 20166139, 20230923
S107 Phosphorylation HPRD 18077418
S256 Phosphorylation HPRD 20068231
S257 Phosphorylation HPRD 19413330
S310 Phosphorylation HPRD 20068231
S312 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD 19413330, 17322306, 18491316, ...18767875, 19651622, 18669648, 20068231, 17924679
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation HPRD   PhosphoSitePlus 20166139, 20230923
Y75 Phosphorylation PhosphoSitePlus
S107 Phosphorylation HPRD 18077418
K248 Ubiquitination PhosphoSitePlus
S254 Phosphorylation HPRD 20068231
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation HPRD   PhosphoSitePlus 17525332, 18077418, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S110 F110 Biomuta DOID:4159 / skin cancer [ cosmic ]
C154 S154 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T243 I243 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S310 T310 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S312 N312 Biomuta DOID:4159 / skin cancer [ cosmic ]