iPTMnet Report for O00267 (SUPT5H)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00267 / SPT5H_HUMAN
Protein Name Transcription elongation factor SPT5
Gene Name Name: SUPT5H
Synonyms:SPT5,SPT5H;
Organism Homo sapiens (Human)

PRO ID PR:O00267
DAG View
PRO Name transcription elongation factor SPT5 (human)
Definition A transcription elongation factor SPT5 that is encoded in the genome of human.
Short Label hSUPT5H
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00267 (SUPT5H) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S2 Phosphorylation RLIMS-P 18157150
S18 O-Glycosylation GlyGen 23301498, 30379171, 30059200, ...29351928, 34019948, 28510447, 31373491
S18 Phosphorylation PhosphoSitePlus
S19 Phosphorylation phospho.ELM 15302935
S32 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
K143 Sumoylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
K323 Acetylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K328 Acetylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K453 Sumoylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
T658 O-Glycosylation GlyGen 23301498, 30379171, 30059200, ...29351928, 34019948, 28510447, 31373491
T658 Phosphorylation PhosphoSitePlus
S666 Phosphorylation P24941 (CDK2) , P28482 (MAPK1) , P06493 (CDK1) , P50750 (CDK9) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 22028470, 23186163, 17081983, ...26728557, 18220336, 18847512, 18234856, 18669648, 20068231
R668 Methylation PhosphoSitePlus
S671 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R681 Methylation PhosphoSitePlus   UniProt 12718890
S686 Phosphorylation PhosphoSitePlus   UniProt 23186163
R696 Methylation PhosphoSitePlus   UniProt 12718890
R698 Methylation PhosphoSitePlus   UniProt 12718890
R700 Methylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
Y717 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
Y720 Phosphorylation PhosphoSitePlus
C740 Methylation IEDB 31844290
S744 Phosphorylation PhosphoSitePlus
R747 Methylation PhosphoSitePlus
R749 Methylation PhosphoSitePlus
R757 Methylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus
S763 O-Glycosylation GlyGen 23301498, 30379171, 30059200, ...29351928, 34019948, 28510447, 31373491
T764 Phosphorylation PhosphoSitePlus
Y765 Phosphorylation PhosphoSitePlus
T768 Phosphorylation P50750 (CDK9) neXtProt   PhosphoSitePlus   Signor 16427012
Y771 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
T775 O-Glycosylation GlyGen 31373491
T775 Phosphorylation P24941 (CDK2) , P50750 (CDK9) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18847512, 27353326, 10757782, ...16427012
Y778 Phosphorylation PhosphoSitePlus
S780 O-Glycosylation GlyGen 31373491
S780 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
R783 Methylation PhosphoSitePlus
T784 Phosphorylation P50750 (CDK9) neXtProt   PhosphoSitePlus   Signor   UniProt 10757782, 16427012
Y787 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus   UniProt 23186163
T791 Phosphorylation P24941 (CDK2) , P50750 (CDK9) neXtProt   PhosphoSitePlus   Signor   UniProt 18847512, 23186163, 16427012
S797 Phosphorylation PhosphoSitePlus
T799 Phosphorylation P50750 (CDK9) neXtProt   PhosphoSitePlus   Signor 16427012
Y802 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus   UniProt 23186163
T806 Phosphorylation P50750 (CDK9) neXtProt   PhosphoSitePlus   Signor   UniProt 23186163, 26728557, 16427012
S812 Phosphorylation PhosphoSitePlus
T814 Phosphorylation P50750 (CDK9) neXtProt   PhosphoSitePlus   Signor 16427012
S818 Phosphorylation PhosphoSitePlus
T828 Phosphorylation PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
S917 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K1017 Ubiquitination PhosphoSitePlus
T1034 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T1036 Phosphorylation PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation HPRD 18452278
S36 Phosphorylation HPRD 18452278
S375 Phosphorylation HPRD 20068231
S666 Phosphorylation HPRD 19413330, 17322306, 18212344, ...20058876, 19691289, 19664995, 19651622, 18669648, 18452278, 19415658, 20068231, 17924679
S670 Phosphorylation HPRD 20068231
S671 Phosphorylation HPRD 18669648, 20068231
S676 Phosphorylation HPRD 20068231
S695 Phosphorylation HPRD 20068231
T709 Phosphorylation HPRD 17924679
Y717 Phosphorylation HPRD 17924679
T791 Phosphorylation HPRD 19413330
T1034 Phosphorylation HPRD 18669648, 17924679, 20068231, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
S104 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049388 (hSUPT5H/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:4159 / skin cancer [ cosmic ]
S36 N36 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S104 F104 Biomuta DOID:4159 / skin cancer [ cosmic ]
S108 F108 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y141 H141 Biomuta [ cosmic ]
K175 R175 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T208 M208 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y230 N230 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y295 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K473 T473 Biomuta DOID:1612 / breast cancer [ cosmic ]
T658 I658 Biomuta DOID:4159 / skin cancer [ cosmic ]
R668 W668 Biomuta DOID:4159 / skin cancer [ cosmic ]
R681 H681 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R696 W696 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R696 M696 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R700 L700 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R700 Q700 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R747 C747 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R747 S747 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R749 Q749 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R749 W749 Biomuta DOID:3571 / liver cancer [ cosmic ]
R757 H757 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T762 I762 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S763 A763 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y765 C765 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S773 P773 Biomuta DOID:4159 / skin cancer [ cosmic ]
T775 M775 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S780 F780 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R783 Q783 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S789 L789 Biomuta DOID:1324 / lung cancer [ cosmic ]
S789 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y802 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S812 C812 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S812 N812 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T814 I814 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S818 G818 Biomuta DOID:184 / bone cancer [ cosmic ]
K1017 N1017 Biomuta DOID:363 / uterine cancer [ icgc ]