Protein Information

Cytoscape View


UniProt AC / UniProt ID O00257 / CBX4_HUMAN
Protein Name E3 SUMO-protein ligase CBX4
Gene Name Name: CBX4
Organism Homo sapiens (Human)

PRO ID PR:O00257
DAG View
PRO Name E3 SUMO-protein ligase CBX4 (human)
Definition An E3 SUMO-protein ligase CBX4 that is encoded in the genome of human.
Short Label hCBX4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00257 (CBX4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y28 Phosphorylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K106 Sumoylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
R137 Methylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus   UniProt 19608861
K149 Sumoylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus   UniProt 23186163
T184 Phosphorylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K205 Sumoylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K212 Sumoylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K249 Methylation PhosphoSitePlus
K249 Sumoylation PhosphoSitePlus
K278 Sumoylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K280 Sumoylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
K365 Sumoylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus   UniProt 24275569
K494 Sumoylation PhosphoSitePlus
T497 Phosphorylation Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   UniProt 17018294
Site PTM Type PTM Enzyme Score Source PMID
S90 Phosphorylation HPRD 19007248
S182 Phosphorylation HPRD 19413330, 19691289
S267 Phosphorylation HPRD 20068231
S293 Phosphorylation HPRD 17081983
S349 Phosphorylation HPRD 18669648, 20068231
T351 Phosphorylation HPRD 18669648
S415 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y120 * Biomuta DOID:3571 / liver cancer [ icgc ]
R137 Q137 Biomuta DOID:1612 / breast cancer [ tcga ]
K149 N149 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y150 * Biomuta DOID:363 / uterine cancer [ tcga ]
K167 N167 Biomuta DOID:3070 / malignant glioma [ tcga ]
K212 E212 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S291 P291 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
S336 R336 Biomuta DOID:1324 / lung cancer [ cosmic ]
S442 I442 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]