Protein Information

Cytoscape View

UniProt AC / UniProt ID O00255 / MEN1_HUMAN
Protein Name Menin
Gene Name Name: MEN1
Organism Homo sapiens (Human)

PRO ID PR:O00255
DAG View
PRO Name menin (human)
Definition A menin that is encoded in the genome of human.
Short Label hMEN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O00255 (MEN1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S122 Phosphorylation RLIMS-P 30792230
K315 Ubiquitination PhosphoSitePlus
S399 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18077418
T402 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S492 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 24275569
S548 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995
S598 Phosphorylation HPRD 20068231
T599 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K609 Methylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S394 Phosphorylation Q13315 (ATM) PhosphoSitePlus 21264250
S487 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
K591 Sumoylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K120 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S548 * Biomuta DOID:0070003 / blastoma [ cosmic ]