iPTMnet Report for O00255 (MEN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00255 / MEN1_HUMAN
Protein Name Menin
Gene Name Name: MEN1
Synonyms:SCG2;
Organism Homo sapiens (Human)

PRO ID PR:O00255
DAG View
PRO Name menin (human)
Definition A menin that is encoded in the genome of human.
Short Label hMEN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00255 (MEN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S122 Phosphorylation RLIMS-P 30792230
S399 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S487 Phosphorylation UniProt 24275569
S543 Phosphorylation UniProt 23186163
T594 Phosphorylation UniProt 18669648, 23186163
T599 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S399 Phosphorylation HPRD 17525332, 18077418
S492 Phosphorylation HPRD 20068231
S548 Phosphorylation HPRD 19413330, 19664995
S598 Phosphorylation HPRD 20068231
T599 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S394 Phosphorylation Q13315 (ATM) HPRD   PhosphoSitePlus 17525332, 18077418, 21264250
S487 Phosphorylation HPRD   PhosphoSitePlus 20068231
S543 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19664995
S583 Phosphorylation PhosphoSitePlus
K591 Sumoylation PhosphoSitePlus
S593 Phosphorylation HPRD 20068231
T594 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K8 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K120 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S492 F492 Biomuta DOID:4159 / skin cancer [ cosmic ]
S548 L548 Biomuta [ cosmic ]
S548 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]