iPTMnet Report for O00220 (TNFRSF10A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00220 / TR10A_HUMAN
Protein Name Tumor necrosis factor receptor superfamily member 10A precursor
Gene Name Name: TNFRSF10A
Synonyms:APO2,DR4,TRAILR1;
Organism Homo sapiens (Human)

PRO ID PR:O00220
DAG View
PRO Name tumor necrosis factor receptor superfamily member 10A (human)
Definition A tumor necrosis factor receptor superfamily member 10A that is encoded in the genome of human.
Short Label hTNFRSF10A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00220 (TNFRSF10A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K36 Ubiquitination PhosphoSitePlus
R52 Methylation PhosphoSitePlus   UniProt 24129315
S83 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S117 O-Glycosylation GlyGen 25813380
T120 O-Glycosylation GlyGen 25813380
S126 O-Glycosylation GlyGen 30459171
N156 N-Glycosylation GlyGen 24190977
N159 N-Glycosylation GlyGen 24190977
N160 N-Glycosylation GlyGen 24190977
S178 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
C336 S-Nitrosylation dbSNO 16847314, 22178444
K391 Ubiquitination PhosphoSitePlus
S424 O-Glycosylation GlyGen   PhosphoSitePlus 30987996
S424 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
K443 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
T461 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S463 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231
S466 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S126 I126 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S424 L424 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S424 A424 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K453 R453 Biomuta DOID:4159 / skin cancer [ cosmic ]