Protein Information

Cytoscape View


UniProt AC / UniProt ID O00213 / APBB1_HUMAN
Protein Name Amyloid-beta A4 precursor protein-binding family B member 1
Gene Name Name: APBB1
Synonyms:FE65,RIR;
Organism Homo sapiens (Human)

PRO ID PR:O00213
DAG View
PRO Name amyloid-beta A4 precursor protein-binding family B member 1 (human)
Definition An amyloid-beta A4 precursor protein-binding family B member 1 that is encoded in the genome of human.
Short Label hAPBB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00213 (APBB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K48 Ubiquitination PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S175 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14697653
S205 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus   RLIMS-P 27176072
S287 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14697653
S289 Phosphorylation PhosphoSitePlus   RLIMS-P 27176072
S347 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14697653
S459 Phosphorylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
Y547 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18922798, 15031292
T579 Phosphorylation PhosphoSitePlus   RLIMS-P 28963516
S610 Phosphorylation O00141 (SGK1) PhosphoSitePlus   RLIMS-P 26188042
K660 Ubiquitination PhosphoSitePlus
C672 S-Nitrosylation dbSNO 26338901
S695 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
T709 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14697653
Site PTM Type PTM Enzyme Score Source PMID
S459 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
S459 Phosphorylation HPRD 20058876


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00213 (APBB1) S610 P05067 (APP) unknown eFIP 26188042
Phosphorylation O00213 (APBB1) Y547 Q9Y272 (RASD1) unknown eFIP 18922798
Phosphorylation Q92993 (KAT5) Y376 O00213 (APBB1) unknown eFIP 24044023


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 T48 Biomuta DOID:363 / uterine cancer [ tcga ]
T82 M82 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S118 F118 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S228 F228 Biomuta DOID:1909 / melanoma [ tcga ]
S287 P287 Biomuta DOID:263 / kidney cancer [ tcga ]
S459 I459 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S517 Y517 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S517 F517 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K536 E536 Biomuta DOID:363 / uterine cancer [ tcga ]
K536 N536 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y547 * Biomuta DOID:3571 / liver cancer [ tcga ]
C672 Y672 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]