Protein Information

Cytoscape View

UniProt AC / UniProt ID O00203 / AP3B1_HUMAN
Protein Name AP-3 complex subunit beta-1
Gene Name Name: AP3B1
Organism Homo sapiens (Human)

PRO ID PR:O00203
DAG View
PRO Name AP-3 complex subunit beta-1 (human)
Definition An AP-3 complex subunit beta-1 that is encoded in the genome of human.
Short Label hAP3B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O00203 (AP3B1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S89 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
Y274 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S276 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 17081983, ...18669648, 23186163, 20068231
T292 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
R519 Methylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
T555 Phosphorylation PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus
K563 Acetylation PhosphoSitePlus
K592 Acetylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
S609 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
T621 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
T661 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K665 Ubiquitination PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus   UniProt 20068231
S752 Phosphorylation PhosphoSitePlus   UniProt 20068231
T810 Phosphorylation PhosphoSitePlus
T862 Phosphorylation PhosphoSitePlus
T1077 Phosphorylation PhosphoSitePlus
S1081 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation Q13535 (ATR) neXtProt 10608806
Site PTM Type PTM Enzyme Score Source PMID
Y274 Phosphorylation HPRD 18669648
S276 Phosphorylation HPRD 19413330, 18691976, 18088087, ...20230923, 18767875, 19651622, 17322306, 18669648, 18707149, 20166139, 20068231
S609 Phosphorylation HPRD 18669648, 19664994, 17081983, ...20068231
T661 Phosphorylation HPRD 18669648
S750 Phosphorylation HPRD 20068231
S752 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K90 T90 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc ]
K125 E125 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S276 C276 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S276 F276 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R519 K519 Biomuta DOID:1324 / lung cancer [ cosmic ]
K602 N602 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T621 N621 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S647 L647 Biomuta DOID:1612 / breast cancer [ icgc ]
S750 G750 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]