Protein Information

Cytoscape View


UniProt AC / UniProt ID O00186 / STXB3_HUMAN
Protein Name Syntaxin-binding protein 3
Gene Name Name: STXBP3
Organism Homo sapiens (Human)

PRO ID PR:O00186
DAG View
PRO Name syntaxin-binding protein 3 (human)
Definition A syntaxin-binding protein 3 that is encoded in the genome of human.
Short Label hSTXBP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00186 (STXBP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
R8 Methylation PhosphoSitePlus
K11 Methylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y219 Phosphorylation RLIMS-P 23937695, 21444687
K220 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
Y521 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 23937695, 21548926, 21444687, ...17916632
S542 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
K570 Acetylation PhosphoSitePlus
K571 Acetylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K577 Acetylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K581 Acetylation PhosphoSitePlus
K583 Acetylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049376 (hSTXBP3/Phos:1) pY521 PRO
PR:000049377 (hSTXBP3/PhosRes+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00186 (STXBP3) Y219 Q12846 (STX4) unknown eFIP 21444687
Phosphorylation O00186 (STXBP3) Y521 Q12846 (STX4) unknown eFIP 17916632


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R8 S8 Biomuta DOID:1612 / breast cancer [ tcga ]
K170 N170 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K214 R214 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K431 N431 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S512 I512 Biomuta DOID:3571 / liver cancer [ icgc ]