iPTMnet Report for O00165 (HAX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00165 / HAX1_HUMAN
Protein Name HCLS1-associated protein X-1
Gene Name Name: HAX1
Synonyms:HS1BP1;
Organism Homo sapiens (Human)

PRO ID PR:O00165
DAG View
PRO Name HCLS1-associated protein X-1 (human)
Definition An HCLS1-associated protein X-1 that is encoded in the genome of human.
Short Label hHAX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00165 (HAX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 25944712
S53 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S135 O-Glycosylation GlyGen 22121020, 35254053
R139 Methylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   UniProt 23186163
S192 Phosphorylation PhosphoSitePlus   UniProt 23186163
K205 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 N2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S66 G66 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S153 F153 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S162 F162 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S189 F189 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S212 P212 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S212 F212 Biomuta DOID:1319 / brain cancer [ icgc ]
S266 F266 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]