Protein Information

Cytoscape View

UniProt AC / UniProt ID O00148 / DX39A_HUMAN
Protein Name ATP-dependent RNA helicase DDX39A
Gene Name Name: DDX39A
Organism Homo sapiens (Human)

PRO ID PR:O00148
DAG View
PRO Name ATP-dependent RNA helicase DDX39A (human)
Definition An ATP-dependent RNA helicase DDX39 that is encoded in the genome of human.
Short Label hDDX39A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O00148 (DDX39A) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895, 20068231
Y13 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K35 Acetylation PhosphoSitePlus   UniProt 19608861
K35 Sumoylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y38 Phosphorylation PhosphoSitePlus
S40 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S43 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
R57 Methylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
K154 Sumoylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
T171 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S183 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
K187 Acetylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
C197 S-Nitrosylation dbSNO 26338901
K199 Ubiquitination PhosphoSitePlus
R207 Methylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K240 Sumoylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K255 Acetylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
K333 Sumoylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
R338 Methylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
R348 Methylation PhosphoSitePlus
T382 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus   UniProt 20068231
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 20068231
S37 Phosphorylation HPRD 20068231
S40 Phosphorylation HPRD 18669648, 20068231
T171 Phosphorylation HPRD 18669648, 19415658, 20068231
S426 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y13 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S37 P37 Biomuta DOID:363 / uterine cancer [ tcga ]
S43 N43 Biomuta DOID:363 / uterine cancer [ tcga ]
K130 R130 Biomuta DOID:1324 / lung cancer [ tcga ]
K154 M154 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K162 T162 Biomuta DOID:1909 / melanoma [ cosmic ]
R207 W207 Biomuta DOID:363 / uterine cancer [ tcga ]
Y264 H264 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R348 Q348 Biomuta DOID:4362 / cervical cancer [ tcga ]
T382 N382 Biomuta DOID:3571 / liver cancer [ icgc ]
S391 F391 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]