iPTMnet Report for O00148 (DDX39A)
Protein Information
UniProt AC / UniProt ID | O00148 / DX39A_HUMAN |
Protein Name | ATP-dependent RNA helicase DDX39A |
Gene Name | Name: DDX39A Synonyms:DDX39; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O00148 |
PRO Name | ATP-dependent RNA helicase DDX39A (human) |
Definition | An ATP-dependent RNA helicase DDX39 that is encoded in the genome of human. |
Short Label | hDDX39A |
Category | organism-gene |
O00148 (DDX39A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330, 22223895, 20068231 | ||
Y13 | Phosphorylation | score1 | PhosphoSitePlus | |||
K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
K35 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K35 | Sumoylation | score1 | PhosphoSitePlus | |||
K35 | Ubiquitination | score1 | PhosphoSitePlus | |||
S37 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
Y38 | Phosphorylation | score1 | PhosphoSitePlus | |||
S40 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S43 | Phosphorylation | score1 | PhosphoSitePlus | |||
K52 | Acetylation | score1 | PhosphoSitePlus | |||
K52 | Sumoylation | score1 | PhosphoSitePlus | |||
K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
R57 | Methylation | score1 | PhosphoSitePlus | |||
C74 | Methylation | score1 | IEDB | 31844290 | ||
K89 | Ubiquitination | score1 | PhosphoSitePlus | |||
K130 | Ubiquitination | score1 | PhosphoSitePlus | |||
K137 | Ubiquitination | score1 | PhosphoSitePlus | |||
S145 | Phosphorylation | score1 | PhosphoSitePlus | |||
K154 | Sumoylation | score1 | PhosphoSitePlus | |||
K155 | Sumoylation | score1 | PhosphoSitePlus | |||
K155 | Ubiquitination | score1 | PhosphoSitePlus | |||
K161 | Acetylation | score1 | PhosphoSitePlus | |||
K161 | Ubiquitination | score1 | PhosphoSitePlus | |||
K162 | Ubiquitination | score1 | PhosphoSitePlus | |||
T171 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
S183 | Phosphorylation | score1 | PhosphoSitePlus | |||
S185 | Phosphorylation | score1 | PhosphoSitePlus | |||
K187 | Acetylation | score1 | PhosphoSitePlus | |||
K187 | Ubiquitination | score1 | PhosphoSitePlus | |||
K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
C197 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K199 | Ubiquitination | score1 | PhosphoSitePlus | |||
R207 | Methylation | score1 | PhosphoSitePlus | |||
T217 | Phosphorylation | score1 | PhosphoSitePlus | |||
K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
K240 | Sumoylation | score1 | PhosphoSitePlus | |||
K240 | Ubiquitination | score1 | PhosphoSitePlus | |||
K255 | Acetylation | score1 | PhosphoSitePlus | |||
K255 | Sumoylation | score1 | PhosphoSitePlus | |||
K255 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y264 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y265 | Phosphorylation | score1 | PhosphoSitePlus | |||
K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
C299 | Methylation | score1 | IEDB | 31844290 | ||
Y329 | Phosphorylation | score1 | PhosphoSitePlus | |||
K333 | Acetylation | score1 | PhosphoSitePlus | |||
K333 | Sumoylation | score1 | PhosphoSitePlus | |||
K333 | Ubiquitination | score1 | PhosphoSitePlus | |||
R338 | Methylation | score1 | PhosphoSitePlus | |||
T343 | Phosphorylation | score1 | PhosphoSitePlus | |||
R348 | Methylation | score1 | PhosphoSitePlus | |||
T382 | Phosphorylation | score1 | PhosphoSitePlus | |||
K383 | Ubiquitination | score1 | PhosphoSitePlus | |||
S391 | Phosphorylation | score1 | PhosphoSitePlus | |||
K397 | Acetylation | score1 | PhosphoSitePlus | |||
K397 | Sumoylation | score1 | PhosphoSitePlus | |||
S426 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
A2 | E2 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y13 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S37 | P37 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S43 | N43 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
R57 | Q57 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
K130 | R130 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc, tcga ] | |
K154 | M154 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K162 | T162 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R207 | Q207 | Biomuta | [ cosmic ] | |
R207 | W207 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
Y264 | H264 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
R348 | Q348 | Biomuta | DOID:4362 / cervical cancer [ icgc ] | |
S391 | F391 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |