iPTMnet Report for O00116 (AGPS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00116 / ADAS_HUMAN
Protein Name Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor
Gene Name Name: AGPS
ORFNames:AAG5;
Organism Homo sapiens (Human)

PRO ID PR:O00116
DAG View
PRO Name alkyldihydroxyacetonephosphate synthase, peroxisomal (human)
Definition An alkyldihydroxyacetonephosphate synthase, peroxisomal that is encoded in the genome of human.
Short Label hAGPS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00116 (AGPS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S42 Phosphorylation IEDB   PhosphoSitePlus 27920218
C58 Methylation IEDB 31844290
S65 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T68 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T72 Phosphorylation HPRD   PhosphoSitePlus 20068231
T74 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T82 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K102 Acetylation PhosphoSitePlus   UniProt 19608861
K102 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
K347 Acetylation PhosphoSitePlus   UniProt 19608861
K347 Ubiquitination PhosphoSitePlus
Y387 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
C413 Methylation IEDB 31844290
K456 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
C552 Methylation IEDB 31844290
C565 Methylation IEDB 31844290
K628 Methylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
Y645 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S42 P42 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C58 Y58 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T68 M68 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T72 A72 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T72 M72 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K92 E92 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T127 A127 Biomuta DOID:4159 / skin cancer [ cosmic ]
K143 T143 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K169 I169 Biomuta DOID:1324 / lung cancer [ cosmic ]
K323 N323 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K389 T389 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K476 Q476 Biomuta DOID:4159 / skin cancer [ cosmic ]
C552 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S632 C632 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]