iPTMnet Report for A6NJ78 (METTL15)
Protein Information
| UniProt AC / UniProt ID | A6NJ78 / MET15_HUMAN |
| Protein Name | 12S rRNA N4-methylcytidine (m4C) methyltransferase precursor |
| Gene Name | Name: METTL15 Synonyms:METT5D1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:A6NJ78 |
| PRO Name | 12S rRNA N4-methylcytidine (m4C) methyltransferase (human) |
| Definition | A 12S rRNA N4-methylcytidine (m4C) methyltransferase that is encoded in the genome of human. |
| Short Label | hMETTL15 |
| Category | organism-gene |
DAG ViewA6NJ78 (METTL15) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T36 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
| K39 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K70 | Methylation | score1 | PhosphoSitePlus | |||
| S85 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T162 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K188 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K352 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S358 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K381 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R395 | Methylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K39 | I39 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K39 | T39 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| T162 | S162 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| K352 | R352 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] |
