iPTMnet Report for A6NI28 (ARHGAP42)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A6NI28 / RHG42_HUMAN
Protein Name Rho GTPase-activating protein 42
Gene Name Name: ARHGAP42
Synonyms:GRAF3;
Organism Homo sapiens (Human)

PRO ID PR:A6NI28
DAG View
PRO Name Rho GTPase-activating protein 42 (human)
Definition A Rho GTPase-activating protein 42 that is encoded in the genome of human.
Short Label hARHGAP42
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A6NI28 (ARHGAP42) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T32 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus   RLIMS-P 28584191, 32331391
T377 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
K731 Methylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
S751 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
T786 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
Y792 Phosphorylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus   UniProt 18669648
T858 Phosphorylation PhosphoSitePlus
Y870 Phosphorylation PhosphoSitePlus   UniProt 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation A6NI28 (ARHGAP42) Y376 Q9QUI0 (Rhoa) unknown eFIP 32331391


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y376 C376 Biomuta DOID:1612 / breast cancer [ cosmic ]
T377 S377 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S641 F641 Biomuta DOID:4159 / skin cancer [ cosmic ]
K731 R731 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S769 L769 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y792 C792 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T858 I858 Biomuta DOID:1324 / lung cancer [ cosmic ]