iPTMnet Report for A6NHR9 (SMCHD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A6NHR9 / SMHD1_HUMAN
Protein Name Structural maintenance of chromosomes flexible hinge domain-containing protein 1
Gene Name Name: SMCHD1
Synonyms:KIAA0650;
Organism Homo sapiens (Human)

PRO ID PR:A6NHR9
DAG View
PRO Name structural maintenance of chromosomes flexible hinge domain-containing protein 1 (human)
Definition A structural maintenance of chromosomes flexible hinge domain-containing protein 1 that is encoded in the genome of human.
Short Label hSMCHD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A6NHR9 (SMCHD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S13 Phosphorylation PhosphoSitePlus
R26 Methylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K591 Acetylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K668 Acetylation PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
S754 Phosphorylation IEDB 32387766
K759 Ubiquitination PhosphoSitePlus
K771 Acetylation PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
K900 Ubiquitination PhosphoSitePlus
K905 Acetylation PhosphoSitePlus
K912 Ubiquitination PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
K1048 Ubiquitination PhosphoSitePlus
K1101 Ubiquitination PhosphoSitePlus
K1119 Ubiquitination PhosphoSitePlus
T1208 Phosphorylation PhosphoSitePlus
T1209 Phosphorylation PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
K1266 Ubiquitination PhosphoSitePlus
K1304 Ubiquitination PhosphoSitePlus
K1349 Acetylation PhosphoSitePlus   UniProt 19608861
K1349 Ubiquitination PhosphoSitePlus
K1358 Acetylation PhosphoSitePlus
K1367 Acetylation PhosphoSitePlus
K1374 Sumoylation PhosphoSitePlus
K1374 Ubiquitination PhosphoSitePlus
K1437 Ubiquitination PhosphoSitePlus
K1441 Ubiquitination PhosphoSitePlus
K1451 Ubiquitination PhosphoSitePlus
T1499 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1503 Phosphorylation PhosphoSitePlus
S1507 Phosphorylation PhosphoSitePlus
K1557 Ubiquitination PhosphoSitePlus
S1580 Phosphorylation IEDB 32387766
T1627 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...28510447, 34725712
T1627 Phosphorylation PhosphoSitePlus
K1628 Ubiquitination PhosphoSitePlus
K1655 Ubiquitination PhosphoSitePlus
K1664 Ubiquitination PhosphoSitePlus
S1697 Phosphorylation PhosphoSitePlus
K1703 Acetylation PhosphoSitePlus
S1709 Phosphorylation PhosphoSitePlus
K1725 Ubiquitination PhosphoSitePlus
S1778 Phosphorylation PhosphoSitePlus
Y1780 Phosphorylation PhosphoSitePlus
K1782 Ubiquitination PhosphoSitePlus
K1788 Ubiquitination PhosphoSitePlus
S1790 Phosphorylation PhosphoSitePlus
K1798 Acetylation PhosphoSitePlus
K1802 Ubiquitination PhosphoSitePlus
K1872 Acetylation PhosphoSitePlus
C1917 Methylation IEDB 31844290
K1918 Ubiquitination PhosphoSitePlus
S1921 Phosphorylation PhosphoSitePlus
K1924 Ubiquitination PhosphoSitePlus
Y1932 Phosphorylation PhosphoSitePlus
T1935 Phosphorylation PhosphoSitePlus
K1950 Ubiquitination PhosphoSitePlus
K1958 Ubiquitination PhosphoSitePlus
T1962 Phosphorylation PhosphoSitePlus
S1970 Phosphorylation PhosphoSitePlus
S1974 Phosphorylation PhosphoSitePlus   UniProt 23186163
C1982 Methylation IEDB 31844290
K2002 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation HPRD 20068231
Y599 Phosphorylation HPRD 17924679
Y609 Phosphorylation HPRD 17924679
T1499 Phosphorylation HPRD 20068231
S1503 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K177 I177 Biomuta DOID:3571 / liver cancer [ cosmic ]
K388 Q388 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K525 N525 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y599 F599 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y609 H609 Biomuta DOID:1319 / brain cancer [ cosmic ]
K771 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K815 T815 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1048 M1048 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1507 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1507 L1507 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1697 L1697 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1709 L1709 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K1918 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S1921 N1921 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]