iPTMnet Report for A5YM69 (ARHGEF35)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A5YM69 / ARG35_HUMAN
Protein Name Rho guanine nucleotide exchange factor 35
Gene Name Name: ARHGEF35
Synonyms:ARHGEF5L;
Organism Homo sapiens (Human)

PRO ID PR:A5YM69
DAG View
PRO Name Rho guanine nucleotide exchange factor 35 (human)
Definition A Rho guanine nucleotide exchange factor 35 that is encoded in the genome of human.
Short Label hARHGEF35
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A5YM69 (ARHGEF35) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S184 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S340 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S464 Y464 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S468 F468 Biomuta DOID:4159 / skin cancer [ cosmic ]