iPTMnet Report for A5YKK6 (CNOT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A5YKK6 / CNOT1_HUMAN
Protein Name CCR4-NOT transcription complex subunit 1
Gene Name Name: CNOT1
Synonyms:CDC39,KIAA1007,NOT1;ORFNames:AD-005;
Organism Homo sapiens (Human)

PRO ID PR:A5YKK6
DAG View
PRO Name CCR4-NOT transcription complex subunit 1 (human)
Definition A CCR4-NOT transcription complex subunit 1 that is encoded in the genome of human.
Short Label hCNOT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A5YKK6 (CNOT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
R45 Methylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
R238 Methylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus   UniProt 23186163
S322 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
C426 Methylation IEDB 31844290
K435 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
C624 S-Nitrosylation dbSNO 26338901
S626 Phosphorylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
T730 Phosphorylation PhosphoSitePlus
T746 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 30379171, 32574038, 34725712, 30059200, 35254053, 35132862, 31492838, 32119511, 36240223, 29351928, 28657654, 29237092
S758 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 30379171, 32574038, 34725712, 30059200, 35254053, 35132862, 31492838, 32119511, 36240223, 29351928, 28657654, 29237092
T764 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 30379171, 32574038, 34725712, 30059200, 35254053, 35132862, 31492838, 32119511, 36240223, 29351928, 28657654, 29237092
K808 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
S827 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 30379171, 32574038, 34725712, 30059200, 35254053, 35132862, 31492838, 32119511, 36240223, 29351928, 28657654, 29237092
Y851 Phosphorylation PhosphoSitePlus
K877 Acetylation PhosphoSitePlus
T880 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28510447, 35138101, 30379171, 32574038, 34725712, 30059200, 35254053, 35132862, 31492838, 32119511, 36240223, 29351928, 28657654, 29237092
K882 Acetylation PhosphoSitePlus
T927 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
Y937 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S1037 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...32938750, 35138101, 30379171, 32574038, 34725712, 28510447, 30059200, 35254053, 35132862, 31492838, 32119511, 36240223, 29351928, 28657654, 29237092
T1038 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...32938750, 35138101, 30379171, 32574038, 34725712, 28510447, 30059200, 35254053, 35132862, 31492838, 32119511, 36240223, 29351928, 28657654, 29237092
T1041 O-Glycosylation GlyGen 32938750, 30059200
T1042 O-Glycosylation GlyGen 32938750, 30059200
S1043 O-Glycosylation GlyGen 32938750, 30059200
T1044 O-Glycosylation GlyGen 31492838
T1047 O-Glycosylation GlyGen 32938750
T1051 O-Glycosylation GlyGen 34846842, 32574038, 32938750, ...30059200, 29351928, 31492838
T1051 Phosphorylation PhosphoSitePlus
T1053 O-Glycosylation GlyGen 32574038
T1053 Phosphorylation PhosphoSitePlus
T1055 O-Glycosylation GlyGen 32574038
T1058 O-Glycosylation GlyGen 29351928
T1058 Phosphorylation PhosphoSitePlus
S1061 O-Glycosylation GlyGen 29351928
S1061 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1063 Acetylation PhosphoSitePlus
K1063 Ubiquitination PhosphoSitePlus
K1064 Ubiquitination PhosphoSitePlus
T1073 Phosphorylation PhosphoSitePlus
K1114 Ubiquitination PhosphoSitePlus
Y1133 Phosphorylation IEDB 32387766
K1163 Ubiquitination PhosphoSitePlus
R1189 Methylation PhosphoSitePlus
K1208 Ubiquitination PhosphoSitePlus
Y1234 Phosphorylation PhosphoSitePlus
K1310 Ubiquitination PhosphoSitePlus
K1320 Ubiquitination PhosphoSitePlus
K1321 Ubiquitination PhosphoSitePlus
T1418 Phosphorylation PhosphoSitePlus
T1419 Phosphorylation PhosphoSitePlus
K1426 Ubiquitination PhosphoSitePlus
S1432 Phosphorylation PhosphoSitePlus
K1514 Acetylation PhosphoSitePlus
K1514 Ubiquitination PhosphoSitePlus
T1525 Phosphorylation PhosphoSitePlus
C1541 Methylation IEDB 31844290
K1560 Ubiquitination PhosphoSitePlus
K1567 Ubiquitination PhosphoSitePlus
K1600 Ubiquitination PhosphoSitePlus
C1615 Methylation IEDB 31844290
S1649 Phosphorylation PhosphoSitePlus
S1703 Phosphorylation PhosphoSitePlus
K1708 Ubiquitination PhosphoSitePlus
S1775 O-Glycosylation GlyGen 29351928
T1780 O-Glycosylation GlyGen 29351928
Y1817 Phosphorylation PhosphoSitePlus
Y1842 Phosphorylation PhosphoSitePlus
K1851 Ubiquitination PhosphoSitePlus
C1932 Methylation IEDB 31844290
Y2074 Phosphorylation PhosphoSitePlus
K2086 Ubiquitination PhosphoSitePlus
C2118 Methylation IEDB 31844290
K2151 Ubiquitination PhosphoSitePlus
K2177 Ubiquitination PhosphoSitePlus
K2178 Ubiquitination PhosphoSitePlus
K2185 Ubiquitination PhosphoSitePlus
S2188 Phosphorylation PhosphoSitePlus
S2194 Phosphorylation PhosphoSitePlus
Y2264 Phosphorylation PhosphoSitePlus
C2286 Methylation IEDB 31844290
K2364 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y928 Phosphorylation HPRD 20068231
S948 Phosphorylation HPRD 20068231
Y951 Phosphorylation HPRD 20068231
T1547 Phosphorylation HPRD 20068231
Y1933 Phosphorylation HPRD 17693683
Y2074 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K808 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K808 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y928 Phosphorylation HPRD 20068231
S948 Phosphorylation HPRD 20068231
Y951 Phosphorylation HPRD 20068231
Y1491 Phosphorylation PhosphoSitePlus
Y1503 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 L7 Biomuta DOID:1612 / breast cancer [ icgc ]
T21 I21 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
K372 E372 Biomuta DOID:1319 / brain cancer [ cosmic ]
K449 N449 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C624 G624 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S725 L725 Biomuta DOID:4159 / skin cancer [ cosmic ]
T764 S764 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T764 N764 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y851 C851 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T880 N880 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T880 A880 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T927 I927 Biomuta DOID:363 / uterine cancer [ icgc ]
S948 F948 Biomuta [ cosmic, cosmic ]
T1041 A1041 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1043 * Biomuta DOID:1612 / breast cancer [ cosmic ]
T1047 N1047 Biomuta DOID:1319 / brain cancer [ icgc ]
T1051 M1051 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1053 M1053 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1055 S1055 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1058 S1058 Biomuta DOID:1612 / breast cancer [ cosmic ]
K1064 N1064 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1114 Q1114 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1189 H1189 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R1189 C1189 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
Y1234 C1234 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1320 T1320 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1418 A1418 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1419 S1419 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1432 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
Y1933 C1933 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1933 F1933 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C2118 S2118 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K2177 R2177 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C2286 R2286 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]