iPTMnet Report for A2RTX5 (TARS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A2RTX5 / SYTC2_HUMAN
Protein Name Threonine--tRNA ligase 2, cytoplasmic
Gene Name Name: TARS3
Synonyms:TARSL2;
Organism Homo sapiens (Human)

PRO ID PR:A2RTX5
DAG View
PRO Name threonine--tRNA ligase 2, cytoplasmic (human)
Definition A threonine--tRNA ligase 2, cytoplasmic that is encoded in the genome of human.
Short Label hTARS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A2RTX5 (TARS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K125 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus   RLIMS-P 31287872
C253 Methylation IEDB 31844290
K322 Ubiquitination PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
T449 Phosphorylation PhosphoSitePlus   RLIMS-P 31287872
S453 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 31287872
Y457 Phosphorylation PhosphoSitePlus   RLIMS-P 31287872
S459 Phosphorylation PhosphoSitePlus   RLIMS-P 31287872
Y619 Phosphorylation PhosphoSitePlus   RLIMS-P 31287872
K662 Methylation PhosphoSitePlus
K663 Methylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y377 C377 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T449 M449 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y619 C619 Biomuta DOID:3571 / liver cancer [ cosmic ]