iPTMnet Report for A1X283 (SH3PXD2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A1X283 / SPD2B_HUMAN
Protein Name SH3 and PX domain-containing protein 2B
Gene Name Name: SH3PXD2B
Synonyms:FAD49,KIAA1295,TKS4;
Organism Homo sapiens (Human)

PRO ID PR:A1X283
DAG View
PRO Name SH3 and PX domain-containing protein 2B (human)
Definition An SH3 and PX domain-containing protein 2B that is encoded in the genome of human.
Short Label hSH3PXD2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A1X283 (SH3PXD2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K17 Acetylation PhosphoSitePlus
Y25 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 20943948, 18083107
Y27 Phosphorylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S279 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S291 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18669648, 20068231
S293 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T353 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y373 Phosphorylation PhosphoSitePlus   RLIMS-P 20943948
Y374 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 20943948
S512 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
K531 Sumoylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K619 Methylation PhosphoSitePlus
T630 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
S679 Phosphorylation HPRD   PhosphoSitePlus 18669648
S699 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
T768 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
K805 Acetylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
T818 Phosphorylation PhosphoSitePlus
K821 Methylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
T829 Phosphorylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
Y855 Phosphorylation HPRD   PhosphoSitePlus 18578522


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation A1X283 (SH3PXD2B) Y508 Q86UR1 (NOXA1) inhibited_association eFIP 20943948
Phosphorylation Q86UR1 (NOXA1) Y110 A1X283 (SH3PXD2B) unknown eFIP 20943948


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 T17 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S293 P293 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y373 C373 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S532 L532 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ]
T735 I735 Biomuta DOID:4159 / skin cancer [ cosmic ]
S772 F772 Biomuta DOID:4159 / skin cancer [ cosmic ]
T818 M818 Biomuta DOID:263 / kidney cancer [ cosmic ]
S853 F853 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y855 C855 Biomuta DOID:3571 / liver cancer [ cosmic ]