iPTMnet Report for A1L390 (PLEKHG3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A1L390 / PKHG3_HUMAN
Protein Name Pleckstrin homology domain-containing family G member 3
Gene Name Name: PLEKHG3
Synonyms:KIAA0599;
Organism Homo sapiens (Human)

PRO ID PR:A1L390
DAG View
PRO Name pleckstrin homology domain-containing family G member 3 (human)
Definition A pleckstrin homology domain-containing family G member 3 that is encoded in the genome of human.
Short Label hPLEKHG3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A1L390 (PLEKHG3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S42 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S76 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 20068231
Y119 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K406 Methylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S576 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S577 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S612 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S636 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S639 Phosphorylation PhosphoSitePlus
S640 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648
S643 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S647 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S656 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S741 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569
S743 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
T782 Phosphorylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S865 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S962 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T964 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1000 Phosphorylation PhosphoSitePlus
S1011 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1020 Phosphorylation PhosphoSitePlus
S1023 Phosphorylation PhosphoSitePlus
T1026 Phosphorylation phospho.ELM 18669648
S1028 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1034 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1037 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S1040 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T1042 Phosphorylation phospho.ELM 18669648, 17081983
T1044 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1046 Phosphorylation PhosphoSitePlus
S1079 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1081 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1092 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
S1102 Phosphorylation PhosphoSitePlus
R1105 Methylation PhosphoSitePlus
R1107 Methylation PhosphoSitePlus   UniProt 24129315
S1115 Phosphorylation PhosphoSitePlus
S1154 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S448 P448 Biomuta DOID:1324 / lung cancer [ cosmic ]
S533 L533 Biomuta DOID:1324 / lung cancer [ cosmic ]
S643 G643 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S743 F743 Biomuta DOID:4159 / skin cancer [ cosmic ]
S783 L783 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S962 I962 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1000 I1000 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1020 F1020 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1023 N1023 Biomuta DOID:363 / uterine cancer [ cosmic ]
S1028 L1028 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1034 F1034 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1079 N1079 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1092 L1092 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1100 C1100 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R1107 W1107 Biomuta DOID:1324 / lung cancer [ cosmic ]