Protein Information

Cytoscape View


UniProt AC / UniProt ID A1L0T0 / HACL2_HUMAN
Protein Name 2-hydroxyacyl-CoA lyase 2
Gene Name Name: ILVBL
Synonyms:AHAS,HACL2;
Organism Homo sapiens (Human)

PRO ID PR:A1L0T0
DAG View
PRO Name 2-hydroxyacyl-CoA lyase 2 (human)
Definition A 2-hydroxyacyl-CoA lyase 2 that is encoded in the genome of human.
Short Label hILVBL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A1L0T0 (ILVBL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T72 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
T121 O-Glycosylation GlyGen 29351928
S141 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
C276 S-Nitrosylation dbSNO 26338901
T297 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T114 M114 Biomuta DOID:10534 / stomach cancer [ tcga ]
T121 K121 Biomuta DOID:3571 / liver cancer [ icgc ]
T121 I121 Biomuta DOID:3070 / malignant glioma [ tcga ]
T297 N297 Biomuta DOID:3571 / liver cancer [ icgc ]