iPTMnet Report for A1IGU5 (ARHGEF37)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A1IGU5 / ARH37_HUMAN
Protein Name Rho guanine nucleotide exchange factor 37
Gene Name Name: ARHGEF37
Organism Homo sapiens (Human)

PRO ID PR:A1IGU5
DAG View
PRO Name Rho guanine nucleotide exchange factor 37 (human)
Definition A Rho guanine nucleotide exchange factor 37 that is encoded in the genome of human.
Short Label hARHGEF37
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A1IGU5 (ARHGEF37) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y175 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
S221 Phosphorylation IEDB 35494241
Y223 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
Y654 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T514 A514 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S518 R518 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S600 C600 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S665 N665 Biomuta DOID:9256 / colorectal cancer [ cosmic ]