iPTMnet Report for A1A4S6 (ARHGAP10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A1A4S6 / RHG10_HUMAN
Protein Name Rho GTPase-activating protein 10
Gene Name Name: ARHGAP10
Synonyms:GRAF2;
Organism Homo sapiens (Human)

PRO ID PR:A1A4S6
DAG View
PRO Name Rho GTPase-activating protein 10 (human)
Definition A Rho GTPase-activating protein 10 that is encoded in the genome of human.
Short Label hARHGAP10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A1A4S6 (ARHGAP10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Acetylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
T530 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
T586 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K140 N140 Biomuta DOID:363 / uterine cancer [ icgc ]
K140 R140 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K147 T147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K154 T154 Biomuta DOID:363 / uterine cancer [ icgc ]
S589 P589 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S600 W600 Biomuta DOID:1612 / breast cancer [ cosmic ]
S600 L600 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]