iPTMnet Report for A0AVT1 (UBA6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A0AVT1 / UBA6_HUMAN
Protein Name Ubiquitin-like modifier-activating enzyme 6
Gene Name Name: UBA6
Synonyms:MOP4,UBE1L2;
Organism Homo sapiens (Human)

PRO ID PR:A0AVT1
DAG View
PRO Name ubiquitin-like modifier-activating enzyme 6 (human)
Definition A ubiquitin-like modifier-activating enzyme 6 that is encoded in the genome of human.
Short Label hUBA6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A0AVT1 (UBA6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S16 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus   UniProt 23186163
K58 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus   UniProt 23186163
K310 Ubiquitination PhosphoSitePlus
S317 O-Glycosylation GlyGen 23301498, 28510447, 29351928
K342 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K544 Acetylation PhosphoSitePlus   UniProt 19608861
K544 Ubiquitination PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
C721 S-Nitrosylation dbSNO 26338901
K729 Ubiquitination PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus   UniProt 23186163
K739 Ubiquitination PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
K800 Ubiquitination PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
K871 Ubiquitination PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
K889 Ubiquitination PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus
K976 Ubiquitination PhosphoSitePlus
K978 Ubiquitination PhosphoSitePlus
Y979 Phosphorylation PhosphoSitePlus
Y994 Phosphorylation PhosphoSitePlus
K1003 Acetylation PhosphoSitePlus
K1003 Ubiquitination PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
T1051 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T637 Phosphorylation HPRD 20068231
S817 Phosphorylation HPRD 20068231
T1016 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 C36 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K115 N115 Biomuta DOID:5041 / esophageal cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, tcga ]
T146 K146 Biomuta DOID:3571 / liver cancer [ icgc ]
K169 Q169 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T241 A241 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S317 R317 Biomuta DOID:2596 / larynx cancer [ cosmic ]
K597 N597 Biomuta DOID:1324 / lung cancer [ tcga ]
S743 C743 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S817 R817 Biomuta DOID:363 / uterine cancer [ tcga ]
K871 T871 Biomuta DOID:1909 / melanoma [ cosmic ]
S951 * Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]