iPTMnet Report for A0AVK6 (E2F8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A0AVK6 / E2F8_HUMAN
Protein Name Transcription factor E2F8
Gene Name Name: E2F8
Organism Homo sapiens (Human)

PRO ID PR:A0AVK6
DAG View
PRO Name transcription factor E2F8 (human)
Definition A transcription factor E2F8 that is encoded in the genome of human.
Short Label hE2F8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A0AVK6 (E2F8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T20 Phosphorylation RLIMS-P 31995441
T43 Phosphorylation PhosphoSitePlus
T44 Phosphorylation RLIMS-P 31995441
T46 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus   UniProt 23186163
C96 Methylation IEDB 31844290
S102 Phosphorylation PhosphoSitePlus   UniProt 23186163
K124 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S358 Phosphorylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus   UniProt 23186163
S416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus   UniProt 23186163
K436 Ubiquitination PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
T681 O-Glycosylation GlyGen 29485866, 35132862, 32938750, ...35254053
S682 O-Glycosylation GlyGen 29485866, 35132862, 35254053
S767 Phosphorylation PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus
T812 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
T863 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T43 I43 Biomuta DOID:1324 / lung cancer [ cosmic ]
S71 T71 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y202 H202 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K211 R211 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S225 N225 Biomuta DOID:4159 / skin cancer [ cosmic ]
S265 F265 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S357 P357 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S358 T358 Biomuta DOID:1324 / lung cancer [ cosmic ]
S664 F664 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S682 L682 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]