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Protein Ontology Report - hPDGFRB/SigPep-/Phos:3

PR:000049847 - http://purl.obolibrary.org/obo/PR_000049847
Ontology Information
PRO ID PR:000049847 Show OBO stanza / PAF
PRO name platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 3 (human)
Synonyms
PRO-short-label: hPDGFRB/SigPep-/Phos:3
PRO-proteoform-std: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046
Definition A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 857 and a phosphoserine at position 1104 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046. [PMID:15271984, PMID:15994317, PRO:KER]
Comment Evidence=(ECO:0000006, based on PMID:15994317). Evidence=(ECO:0000006, based on PMID:15271984). Kinase=("PDGFRB"; PR:P09619; Tyr-857). Kinase=("GRK2"; PR:000003791; Ser-1104).
PRO Category organism-modification
Parent PR:P09619 platelet-derived growth factor receptor beta (human)
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Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000049847
hPDGFRB/SigPep-/Phos:3
Tyr-857, MOD:00048|Ser-1104, MOD:00046
capable_of GO:0005515 protein binding decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 with PR:O14745 hSLC9A3R1 PMID:15271984
capable_of GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
participates_in GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2 PMID:15271984
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling PR:000049847 hPDGFRB/SigPep-/Phos:3
Tyr-857, MOD:00048|Ser-1104, MOD:00046
decreased relative to PR:000049846 hPDGFRB/SigPep-/Phos:2
PMID:15271984

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