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Protein Ontology Report - mCELA2A/mature

PR:000037245 - http://purl.obolibrary.org/obo/PR_000037245
Ontology Information
PRO ID PR:000037245 Show OBO stanza / PAF
PRO name chymotrypsin-like elastase family member 2A, mature form (mouse)
Synonyms
PRO-short-label: mCELA2A/mature
PRO-proteoform-ftid: PRO_0000027688
PRO-proteoform-std: UniProtKB:P05208, 31-271
RELATED: Cela2a (mouse); Ela2 (mouse); elastase 2 (mouse)
Definition A chymotrypsin-like elastase family member 2A, pro-form (mouse) that has had the activation peptide removed by proteolytic cleavage. UniProtKB:P05208, 31-271. [PMID:20179351, PMID:3641189, PRO:KRC]
Comment Note: Figure 3C in PMID:20179351 shows the Western blot analysis of WT and Tg-ELA2 (Tg) epidermal and dermal extracts, using an anti-FLAG antibody, revealing exogenous ELA2flag as pro-forms and active forms in the epidermis of transgenic animals. Figure 1 in PMID:3641189 shows sequence of mRNA corresponding to preproenzyme and presumes start site of active enzyme based on homology with porcine enzyme.
PRO Category organism-modification
Parent PR:000037244 chymotrypsin-like elastase family member 2A, pro-form (mouse)
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037245
mCELA2A/mature
capable_of GO:0017171 serine hydrolase activity MGI:4440399, PMID:20179351
capable_of GO:0017171 serine hydrolase activity MGI:4440399, PMID:20179351
participates_in GO:0006508 proteolysis MGI:4440399, PMID:20179351
participates_in GO:0061436 establishment of skin barrier MGI:4440399, PMID:20179351
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006508 proteolysis PR:000037245 mCELA2A/mature

MGI:4440399, PMID:20179351
GO:0061436 establishment of skin barrier PR:000037245 mCELA2A/mature

MGI:4440399, PMID:20179351

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