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Protein Ontology Report - KCND2

PR:000000785 - http://purl.obolibrary.org/obo/PR_000000785
Ontology Information
PRO ID PR:000000785 Show OBO stanza / PAF
PRO name voltage-gated potassium channel KCND2
Synonyms
PRO-short-label: KCND2
EXACT: voltage-gated potassium channel subunit Kv4.2
Gene-based: KIAA1044
Definition A shal-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCND2 gene or a 1:1 ortholog thereof. Kv4.2 potassium channels play a critical role in postsynaptic excitability. They are modulated by phosphorylation as well as by association with Kv4 Channel Interacting Proteins (KChIPs). The N terminus contains an ER retention motif RKR that seems to be masked when associated to KChiPs. This masking increases surface expression. [PMID:12829703, PRO:CNA]
PRO Category gene
Parent PR:000000710 shal-related voltage-gated potassium channel alpha subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 2
modification 5 organism-modification 6
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000045389
mKCND2/iso:1/UnPhos:3
Ser-552, PR:000026291 		located_in GO:0009986 cell surface PMID:12829703, PMID:16251476
PR:Q9Z0V2-1
mKCND2/iso:1
located_in GO:0005783 endoplasmic reticulum PMID:12829703
PR:Q9NZV8-1
hKCND2/iso:1
located_in GO:0009986 cell surface PMID:12493773
participates_in GO:0007268 chemical synaptic transmission PMID:11102480
participates_in GO:0001508 action potential PMID:11102480
PR:000036580
mKCND2/iso:1/Phos:4
Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046 		capable_of GO:0005250 A-type (transient outward) potassium channel activity PMID:16251476
located_in GO:0030425 dendrite PMID:11040264
located_in GO:0009986 cell surface PMID:16251476
PR:000045390
mKCND2/iso:1/UnPhos:4
Thr-602/Thr-607/Ser-616, PR:000026291 		capable_of GO:0005250 A-type (transient outward) potassium channel activity PMID:16251476
PR:000036579
mKCND2/iso:1/Phos:3
Ser-552, MOD:00046 		located_in GO:0030425 dendrite PMID:11040264
PR:000036578
mKCND2/iso:1/Phos:2
Thr-38, MOD:00047 		located_in GO:0030425 dendrite PMID:11040264
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0001508 action potential PR:Q9NZV8-1 hKCND2/iso:1

PMID:11102480
GO:0007268 chemical synaptic transmission PR:Q9NZV8-1 hKCND2/iso:1

PMID:11102480
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009986 cell surface PR:000036580 mKCND2/iso:1/Phos:4
Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046
PMID:16251476
PR:000045389 mKCND2/iso:1/UnPhos:3
Ser-552, PR:000026291
PMID:12829703, PMID:16251476
PR:Q9NZV8-1 hKCND2/iso:1

PMID:12493773
GO:0030425 dendrite PR:000036578 mKCND2/iso:1/Phos:2
Thr-38, MOD:00047
PMID:11040264
PR:000036579 mKCND2/iso:1/Phos:3
Ser-552, MOD:00046
PMID:11040264
PR:000036580 mKCND2/iso:1/Phos:4
Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046
PMID:11040264
GO:0005783 endoplasmic reticulum PR:Q9Z0V2-1 mKCND2/iso:1

PMID:12829703

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