| PRO ID |
PR:000000710
Show OBO stanza
|
| PRO name |
shal-related voltage-gated potassium channel alpha subunit |
| Synonyms |
| PRO-short-label: |
fam:Kchan_shal_sub-a |
| RELATED: |
A-type potassium channel; Kv4; pore-forming Kv4 alpha subunits |
|
| Definition |
A voltage-gated potassium channel alpha subunit that is a constituent of the Kv4 channels, responsible for transient, voltage-dependent potassium currents (A currents) in the brain and heart. The unique motif KSCASE is absolutely conserved in all shal-related channel subunits. Mutations in this region drastically affect deactivation and inactivation. This motif is located in the cytoplasmic S4-S5 loop. In common with Kv2 and Kv3 channels, the tetramerization domain at the N terminus contains a zinc binding site. Kv.4 channels are modulated by Kv4 Channel Interacting Proteins (KChIPs1-4), which bind to the cytoplasmic N-terminal domain.
[PMID:15555915]
|
| PRO Category |
family |
| Parent |
PR:000000685 voltage-gated potassium channel alpha subunit |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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