[Term]
id: PR:000000996
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the carboxyl-terminal cytoplasmic domain by cAMP-dependent protein kinase (PKA). Phosphorylation occurs at the conserved Ser within the motif [RQ]GS[IV]QEL. Example: UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046." [PRO:CNA]
comment: Category=modification.
synonym: "KCND2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000988 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000997
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the carboxyl-terminal cytoplasmic domain by ERK at the three most C-terminal consensus motifs (minimal motif=a Ser or Thr followed directly by a proline). Example: UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046." [PMID:11080179]
comment: Category=modification.
synonym: "KCND2/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000988 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000000994
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the amino- and carboxyl-terminal cytoplasmic domains by cAMP-dependent protein kinase (PKA). At the N terminus, the phosporylation occurs at a Thr residue within the PKA consensus phosphorylation sequence adjacent to the first transmembrane domain (segment S1). At the C-terminus, it occurs at the conserved Ser within the motif [RQ]GS[IV]QEL. Example: UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047|Ser-552, MOD:00046." [PMID:10681507]
comment: Category=modification.
synonym: "KCND2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000988 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000000995
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated form in which the phosphorylation occurs within the amino-terminal cytoplasmic domain by cAMP-dependent protein kinase (PKA). The phosporylation occurs at a Thr residue within the PKA consensus phosphorylation sequence adjacent to the first transmembrane domain (segment S1). Example: UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047." [PMID:11040264]
comment: Category=modification.
synonym: "KCND2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000988 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q9Z0V2-1
name: potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse)
def: "A voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mKCND2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z0V2-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000947 ! voltage-gated potassium channel KCND2 isoform 1

[Term]
id: PR:000045389
name: voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse)
def: "A potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse) that lacks phosphorylation on Ser-552. UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291." [PMID:12829703, PRO:CNA]
comment: Category=organism-modification.
synonym: "mKCND2/iso:1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9Z0V2-1 ! potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000000988
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated form
def: "A voltage-gated potassium channel KCND2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "KCND2/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000947 ! voltage-gated potassium channel KCND2 isoform 1

[Term]
id: PR:000000785
name: voltage-gated potassium channel KCND2
def: "A shal-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCND2 gene or a 1:1 ortholog thereof. Kv4.2 potassium channels play a critical role in postsynaptic excitability. They are modulated by phosphorylation as well as by association with Kv4 Channel Interacting Proteins (KChIPs). The N terminus contains an ER retention motif RKR that seems to be masked when associated to KChiPs. This masking increases surface expression." [PMID:12829703, PRO:CNA]
comment: Category=gene.
synonym: "KCND2" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1044" RELATED Gene-based []
synonym: "voltage-gated potassium channel subunit Kv4.2" EXACT []
xref: IUPHARobj:553
is_a: PR:000000710 ! shal-related voltage-gated potassium channel alpha subunit

[Term]
id: PR:000045390
name: voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse)
def: "A potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse) that lacks phosphorylation on Thr-602, Thr-607, and Ser-616. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291." [PMID:16251476, PRO:CNA]
comment: Category=organism-modification.
synonym: "mKCND2/iso:1/UnPhos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9Z0V2-1 ! potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000000947
name: voltage-gated potassium channel KCND2 isoform 1
def: "A voltage-gated potassium channel KCND2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZV8-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "Kv4.2" EXACT []
synonym: "KCND2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000785 ! voltage-gated potassium channel KCND2

[Term]
id: PR:Q5VSI1
name: uncharacterized protein, kcnd2 translation product (zebrafish)
def: "A voltage-gated potassium channel KCND2 that is encoded in the genome of zebrafish." [PRO:CNA]
comment: Category=organism-gene.
synonym: "z-KCND2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5VSI1
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000000785 ! voltage-gated potassium channel KCND2
relationship: has_gene_template ZFIN:ZDB-GENE-041210-70 ! kcnd2 (zebrafish)

[Term]
id: PR:Q9NZV8-1
name: potassium voltage-gated channel subfamily D member 2 isoform 1 (human)
def: "A voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hKCND2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NZV8-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000947 ! voltage-gated potassium channel KCND2 isoform 1

[Term]
id: PR:000036577
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse)
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047|Ser-552, MOD:00046." [PMID:10681507, PRO:CNA]
comment: Category=organism-modification.
synonym: "mKCND2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047|Ser-552, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000994 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q9NZV8
name: potassium voltage-gated channel subfamily D member 2 (human)
def: "A voltage-gated potassium channel KCND2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NZV8]
comment: Category=organism-gene.
synonym: "KCND2" RELATED Gene-based [UniProtKB:Q9NZV8]
synonym: "hKCND2" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1044" RELATED Gene-based [UniProtKB:Q9NZV8]
synonym: "voltage-gated potassium channel subunit Kv4.2 (human)" EXACT [UniProtKB:Q9NZV8]
xref: UniProtKB:Q9NZV8
xref: Reactome:R-HSA-977453 "PR:Q9NZV8 located_in GO:0005886"
xref: DTO:01100194
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000785 ! voltage-gated potassium channel KCND2
relationship: has_gene_template HGNC:6238 ! KCND2 (human)

[Term]
id: PR:000036580
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse)
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 in mouse. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046." [PMID:11040264, PMID:16251476, PRO:CNA]
comment: Category=organism-modification.
synonym: "mKCND2/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000997 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q9Z0V2
name: potassium voltage-gated channel subfamily D member 2 (mouse)
def: "A voltage-gated potassium channel KCND2 that is encoded in the genome of mouse." [OMA:Q9Z0V2, PRO:DNx]
comment: Category=organism-gene.
synonym: "Kcnd2" RELATED Gene-based [UniProtKB:Q9Z0V2]
synonym: "mKCND2" EXACT PRO-short-label [PRO:DNx]
synonym: "Kiaa1044" RELATED Gene-based [UniProtKB:Q9Z0V2]
synonym: "MNCb-7013" RELATED Gene-based [UniProtKB:Q9Z0V2]
synonym: "voltage-gated potassium channel subunit Kv4.2 (mouse)" EXACT [UniProtKB:Q9Z0V2]
xref: UniProtKB:Q9Z0V2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000785 ! voltage-gated potassium channel KCND2
relationship: has_gene_template MGI:102663 ! Kcnd2 (mouse)

[Term]
id: PR:000036579
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse)
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046." [PMID:11040264, PRO:CNA]
comment: Category=organism-modification.
synonym: "mKCND2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000996 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036578
name: voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse)
def: "A voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047." [PMID:11040264, PRO:CNA]
comment: Category=organism-modification.
synonym: "mKCND2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000995 ! voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2
relationship: has_part MOD:00047 ! O-phospho-L-threonine