[Term]
id: PR:000000622
name: TGF-beta 1 sequence variant R218C cleaved 2 (human)
def: "A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]
comment: Category=organism-modification.
synonym: "hTGFB1/var:R218C/Clv:2" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "TGF-beta 1 sequence variant 3 cleaved 2 (human)" EXACT [PRO:DAN]
is_a: PR:000021904 ! TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
relationship: output_of GO:0016485 ! protein processing
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens