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Protein Ontology Report - THBS1

PR:000000129 - http://purl.obolibrary.org/obo/PR_000000129
Ontology Information
PRO ID PR:000000129 Show OBO stanza / PAF
PRO name thrombospondin-1
Synonyms
PRO-short-label: THBS1
EXACT: glycoprotein G
Gene-based: TSP; TSP1
Definition A thrombospondin subgroup A that is a translation product of the human THBS1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000029 thrombospondin subgroup A
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 3
modification 7 organism-modification 15
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

THBS1 forms found in complexes
THBS1 Component Complexes
PR:000028410 hTHBS1/SigPep- PR:000028445 integrin alphaIIbbeta3:thrombospondin 1 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000129
THBS1
participates_in GO:0007596 blood coagulation PANTHER:PTHR10199:SF37
PR:000036487
mTHBS1/iso:1/SigPep-/GlycoRes+
MOD:00222|MOD:00812|MOD:00813 		capable_of GO:0005515 protein binding with PR:000036486 mTHBS1/iso:1/Clv:2 PMID:1459996
capable_of GO:0050431 transforming growth factor beta binding PMID:9657149
located_in GO:0005615 extracellular space PMID:9657149
PR:000028410
hTHBS1/SigPep-
located_in GO:0005615 extracellular space PMID:15662972
PR:000036485
mTHBS1/iso:1/SigPep-
located_in GO:0005615 extracellular space PMID:12498716
PR:000036490
mTHBS1/iso:1/Clv:2/GlycoRes+
MOD:00693 		participates_in GO:0016525 negative regulation of angiogenesis PMID:17082774
participates_in GO:0060055 angiogenesis involved in wound healing PMID:17082774
PR:000036486
mTHBS1/iso:1/Clv:2
capable_of GO:0042802 identical protein binding with PR:000036486 mTHBS1/iso:1/Clv:2 PMID:17082774
participates_in GO:0060055 angiogenesis involved in wound healing PMID:17082774
participates_in GO:0016525 negative regulation of angiogenesis PMID:17082774
PR:000036488
hTHBS1/iso:1/SigPep-/Glyco:1
Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813 		capable_of GO:0050431 transforming growth factor beta binding PMID:15342643
capable_of GO:0005515 protein binding with PR:000028966 hTHBS1/iso:1/Clv:2 PMID:3305519
PR:000044495
mTHBS1/SigPep-
located_in GO:0005615 extracellular space PMID:12498716
PR:000026338
hTHBS1/iso:1/SigPep-
capable_of GO:0004866 endopeptidase inhibitor activity PMID:8751720
located_in GO:0005615 extracellular space PMID:15662972
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007596 blood coagulation PR:000000129 THBS1

PANTHER:PTHR10199:SF37
GO:0016525 negative regulation of angiogenesis PR:000036486 mTHBS1/iso:1/Clv:2

PMID:17082774
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+
MOD:00693
PMID:17082774
GO:0060055 angiogenesis involved in wound healing PR:000036486 mTHBS1/iso:1/Clv:2

PMID:17082774
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+
MOD:00693
PMID:17082774
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000026338 hTHBS1/iso:1/SigPep-

PMID:15662972
PR:000028410 hTHBS1/SigPep-

PMID:15662972
PR:000036485 mTHBS1/iso:1/SigPep-

PMID:12498716
PR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+
MOD:00222|MOD:00812|MOD:00813
PMID:9657149
PR:000044495 mTHBS1/SigPep-

PMID:12498716

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