[Term]
id: PR:P07996
name: thrombospondin-1 (human)
def: "A thrombospondin-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07996]
comment: Category=organism-gene.
synonym: "TSP" RELATED Gene-based [UniProtKB:P07996]
synonym: "TSP1" RELATED Gene-based [UniProtKB:P07996]
synonym: "THBS1" RELATED Gene-based [UniProtKB:P07996]
synonym: "hTHBS1" EXACT PRO-short-label [PRO:DNx]
synonym: "glycoprotein G (human)" EXACT [UniProtKB:P07996]
xref: UniProtKB:P07996
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000129 ! thrombospondin-1
relationship: has_gene_template HGNC:11785 ! THBS1 (human)

[Term]
id: PR:000025437
name: thrombospondin-1 proteolytic cleavage product
def: "A thrombospondin-1 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "THBS1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000129 ! thrombospondin-1

[Term]
id: PR:P35441-1
name: thrombospondin-1 isoform 1 (mouse)
def: "A thrombospondin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTHBS1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35441-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000376 ! thrombospondin-1 isoform 1

[Term]
id: PR:000054418
name: thrombospondin-1 N-glycosylated 5 (human)
def: "A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G59626AS." [GlyGen:P07996-1, PMID:23345538, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTHBS1/NGlyco:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G59626AS" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P07996 ! thrombospondin-1 (human)
relationship: has_part GNO:G59626AS ! G59626AS
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054419
name: thrombospondin-1 N-glycosylated 6 (human)
def: "A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-360 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G87051GH. Example: UniProtKB:P07996-1, Asn-360, MOD:00160~GNO:G87051GH." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTHBS1/NGlyco:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, Asn-360, MOD:00160~GNO:G87051GH" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P07996 ! thrombospondin-1 (human)
relationship: has_part GNO:G87051GH ! G87051GH
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036490
name: thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
def: "A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in mouse. UniProtKB:P35441-1, 312-1170, MOD:00693." [PMID:17082774, PRO:CNA]
comment: Category=organism-modification.
synonym: "mTHBS1/iso:1/Clv:2/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35441-1, 312-1170, MOD:00693" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000590 ! thrombospondin-1 isoform 1 cleaved 2 glycosylated form
relationship: has_part MOD:00693 ! glycosylated residue

[Term]
id: PR:000054416
name: thrombospondin-1 N-glycosylated 3 (human)
def: "A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G27126ED. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G27126ED." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTHBS1/NGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G27126ED" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P07996 ! thrombospondin-1 (human)
relationship: has_part GNO:G27126ED ! G27126ED
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054414
name: thrombospondin-1 N-glycosylated 1 (human)
def: "A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G09197ZW. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G09197ZW." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTHBS1/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G09197ZW" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P07996 ! thrombospondin-1 (human)
relationship: has_part GNO:G09197ZW ! G09197ZW
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054415
name: thrombospondin-1 N-glycosylated 2 (human)
def: "A thrombospondin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-1067 of the amino acid sequence represented by UniProtKB:P07996-1, in which the glycan composition is represented by GlyTouCan:G16175ZV. Example: UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G16175ZV." [GlyGen:P07996-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hTHBS1/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, Asn-1067, MOD:00160~GNO:G16175ZV" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P07996 ! thrombospondin-1 (human)
relationship: has_part GNO:G16175ZV ! G16175ZV
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000129
name: thrombospondin-1
def: "A thrombospondin subgroup A that is a translation product of the human THBS1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "TSP" RELATED Gene-based []
synonym: "TSP1" RELATED Gene-based []
synonym: "THBS1" EXACT PRO-short-label [PRO:DNx]
synonym: "glycoprotein G" EXACT []
xref: PANTHER:PTHR10199:SF37
is_a: PR:000000029 ! thrombospondin subgroup A

[Term]
id: PR:000000589
name: thrombospondin-1 isoform 1, signal peptide removed glycosylated form
def: "A thrombospondin-1 isoform 1, signal peptide removed form that has been post-translationally modified to include C-mannosylation on WxxW patterns, and O-fucosylation in CSx[ST]CG motif." [PMID:11067851, PRO:CNA]
comment: Category=modification.
synonym: "THBS1/iso:1/SigPep-/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "thrombospondin-1 isoform 1 cleaved and glycosylated 1" EXACT []
is_a: PR:000000587 ! thrombospondin-1 isoform 1, signal peptide removed form
relationship: has_part MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan
relationship: has_part MOD:00812 ! O-fucosyl-L-serine
relationship: has_part MOD:00813 ! O-fucosyl-L-threonine

[Term]
id: PR:000000588
name: thrombospondin-1 isoform 1 cleaved 2
def: "A thrombospondin-1 isoform 1 that has been proteolytically processed by ADAMTS1 to render an N-terminal domain product." [PMID:17082774]
comment: Category=modification.
synonym: "THBS1/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000376 ! thrombospondin-1 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:P35441
name: thrombospondin-1 (mouse)
def: "A thrombospondin-1 that is encoded in the genome of mouse." [OMA:P35441, PRO:DNx]
comment: Category=organism-gene.
synonym: "Tsp1" RELATED Gene-based [UniProtKB:P35441]
synonym: "Thbs1" RELATED Gene-based [UniProtKB:P35441]
synonym: "mTHBS1" EXACT PRO-short-label [PRO:DNx]
synonym: "glycoprotein G (mouse)" EXACT [UniProtKB:P35441]
xref: UniProtKB:P35441
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000129 ! thrombospondin-1
relationship: has_gene_template MGI:98737 ! Thbs1 (mouse)

[Term]
id: PR:000000587
name: thrombospondin-1 isoform 1, signal peptide removed form
def: "A thrombospondin-1 isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:CNA]
comment: Category=modification.
synonym: "THBS1/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "thrombospondin-1 isoform 1 cleaved 1" EXACT []
intersection_of: PR:000000376 ! thrombospondin-1 isoform 1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000000485
name: thrombospondin-1 isoform 1 cleaved and glycosylated form
def: "A thrombospondin-1 isoform 1, signal peptide removed form that has been processed by proteolytic cleavage and includes at least one glycosylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "THBS1/iso:1/ClvGlyco+" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000587 ! thrombospondin-1 isoform 1, signal peptide removed form
relationship: output_of GO:0016485 ! protein processing
relationship: has_part MOD:00693 ! glycosylated residue

[Term]
id: PR:000028966
name: thrombospondin-1 isoform 1 cleaved 2 (human)
def: "A thrombospondin-1 isoform 1 cleaved 2 in human. UniProtKB:P07996-1, 19-311." [PRO:DAN]
comment: Category=organism-modification.
synonym: "hTHBS1/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-311" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000588 ! thrombospondin-1 isoform 1 cleaved 2

[Term]
id: PR:000026338
name: thrombospondin-1 isoform 1, signal peptide removed form (human)
def: "A thrombospondin-1 isoform 1, signal peptide removed form in human. UniProtKB:P07996-1, 19-1170." [PRO:DNx, UniProtKB:P07996]
comment: Category=organism-modification.
synonym: "PRO_0000035842" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTHBS1/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-1170" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000587 ! thrombospondin-1 isoform 1, signal peptide removed form

[Term]
id: PR:000000376
name: thrombospondin-1 isoform 1
def: "A thrombospondin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07996-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "THBS1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000129 ! thrombospondin-1

[Term]
id: PR:000028410
name: thrombospondin-1, signal peptide removed form (human)
def: "A thrombospondin-1, signal peptide removed form in human. Example: UniProtKB:P07996-1, 19-1170." [PRO:DNx]
comment: Category=organism-modification.
synonym: "PRO_0000035842" NARROW PRO-proteoform-ftid [PRO:DAN]
synonym: "hTHBS1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-1170" NARROW PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-66518 "PR:000028410 located_in GO:0005576"
xref: Reactome:R-HSA-5173263 "PR:000028410 located_in GO:0005788"
xref: Reactome:R-HSA-114701 "PR:000028410 located_in GO:0031093"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000018282 ! thrombospondin-1, signal peptide removed form

[Term]
id: PR:000036485
name: thrombospondin-1 isoform 1, signal peptide removed form (mouse)
def: "A thrombospondin-1 isoform 1, signal peptide removed form in mouse. UniProtKB:P35441-1, 19-1170." [PMID:12498716, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000035843" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "mTHBS1/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35441-1, 19-1170" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000587 ! thrombospondin-1 isoform 1, signal peptide removed form

[Term]
id: PR:000036487
name: thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
def: "A thrombospondin-1 isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813." [PMID:1459996, PMID:9657149, PRO:CNA]
comment: Category=organism-modification.
synonym: "mTHBS1/iso:1/SigPep-/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000035843, MOD:00222|MOD:00812|MOD:00813" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000589 ! thrombospondin-1 isoform 1, signal peptide removed glycosylated form
relationship: has_part MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan
relationship: has_part MOD:00812 ! O-fucosyl-L-serine
relationship: has_part MOD:00813 ! O-fucosyl-L-threonine

[Term]
id: PR:000036486
name: thrombospondin-1 isoform 1 cleaved 2 (mouse)
def: "A thrombospondin-1 isoform 1 cleaved 2 in mouse. UniProtKB:P35441-1, 19-311." [PMID:17082774, PRO:CNA]
comment: Category=organism-modification.
synonym: "mTHBS1/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35441-1, 19-311" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000588 ! thrombospondin-1 isoform 1 cleaved 2

[Term]
id: PR:000036489
name: thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
def: "A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTHBS1/iso:1/Clv:2/Glyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000000590 ! thrombospondin-1 isoform 1 cleaved 2 glycosylated form
relationship: has_part MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan
relationship: has_part MOD:00812 ! O-fucosyl-L-serine
relationship: has_part MOD:00813 ! O-fucosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036488
name: thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
def: "A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTHBS1/iso:1/SigPep-/Glyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000035842, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000000589 ! thrombospondin-1 isoform 1, signal peptide removed glycosylated form
relationship: has_part MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan
relationship: has_part MOD:00812 ! O-fucosyl-L-serine
relationship: has_part MOD:00813 ! O-fucosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044495
name: thrombospondin-1, signal peptide removed form (mouse)
def: "A thrombospondin-1, signal peptide removed form in mouse." [PMID:12498716, PMID:8654563, PRO:CNA]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8654563).
synonym: "mTHBS1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000018282 ! thrombospondin-1, signal peptide removed form

[Term]
id: PR:P07996-1
name: thrombospondin-1 isoform 1 (human)
def: "A thrombospondin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTHBS1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07996-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000376 ! thrombospondin-1 isoform 1

[Term]
id: PR:P07996-2
name: thrombospondin-1 isoform 2 (human)
def: "A thrombospondin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07996-2." [PRO:DNx, UniProtKB:P07996]
comment: Category=organism-sequence.
synonym: "hTHBS1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07996-2
is_a: PR:P07996 ! thrombospondin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000018282
name: thrombospondin-1, signal peptide removed form
def: "A thrombospondin-1 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "THBS1/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000129 ! thrombospondin-1
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000000590
name: thrombospondin-1 isoform 1 cleaved 2 glycosylated form
def: "A thrombospondin-1 isoform 1 cleaved and glycosylated form that has been proteolytically processed by ADAMTS1 to render a C-terminal domain product." [PMID:17082774]
comment: Category=modification.
synonym: "THBS1/iso:1/Clv:2/GlycoRes+" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000485 ! thrombospondin-1 isoform 1 cleaved and glycosylated form
relationship: has_part MOD:00693 ! glycosylated residue