Protein Ontology Report - hKCNQ2 PR:O43526 - http://purl.obolibrary.org/obo/PR_O43526

This page represents a class of proteins encompassing all the protein products of the KCNQ2 gene in human .

Ontology Information
PRO ID	PR:O43526 Show OBO stanza / PAF
PRO name	potassium voltage-gated channel subfamily KQT member 2 (human)
Synonyms	PRO-short-label: hKCNQ2 EXACT: KQT-like 2 (human); neuroblastoma-specific potassium channel subunit alpha KvLQT2 (human); voltage-gated potassium channel subunit Kv7.2 (human) Gene-based: KCNQ2
Definition	A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human.
PRO Category	organism-gene
Parent	PR:000000729 voltage-gated potassium channel subunit KCNQ2
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 16 organism-modification 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:01100233, HGNC:6296, Reactome:R-HSA-443613, UniProtKB:O43526

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000000911 hKCNQ2/var:4 Arg-214, CHEBI:29954 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:11175290 PR:000000915 hKCNQ2/var:M208V Met-208, CHEBI:30015 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:14534157 PR:000000909 hKCNQ2/var:R207W Arg-207, CHEBI:29954 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:11572947 capable_of GO:0005249 voltage-gated potassium channel activity decreased relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:11572947 PR:000000908 hKCNQ2/var:H228Q His-228, CHEBI:30011 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:14534157 PR:000000910 hKCNQ2/var:L243F Leu-243, CHEBI:29997 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:14534157 PR:000000916 hKCNQ2/iso:3/var:K526N Lys-526, CHEBI:50347 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:15249611 PR:O43526-4 hKCNQ2/iso:4 capable_of GO:0005251 delayed rectifier potassium channel activity PMID:9836639 PR:000000914 hKCNQ2/var:R333Q Arg-333, CHEBI:30011 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:14534157 PR:O43526-6 hKCNQ2/iso:6 capable_of GO:0005249 voltage-gated potassium channel activity PMID:9039501 PR:000000912 hKCNQ2/var:Y284C Tyr-284, CHEBI:29950 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:10788442 located_in GO:0009986 cell surface PMID:10788442 PR:000000913 hKCNQ2/var:A306T Ala-306, CHEBI:30013 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:10788442 located_in GO:0009986 cell surface PMID:10788442 PR:000000907 hKCNQ2/var:S247W Ser-247, CHEBI:29954 associated_with_disease_progression DOID:14264 benign neonatal seizures PMID:12742592 capable_of GO:0005249 voltage-gated potassium channel activity decreased relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:12742592 PR:O43526-2 hKCNQ2/iso:2 capable_of GO:0005249 voltage-gated potassium channel activity PMID:11160379 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0009986 cell surface PR:000000912 hKCNQ2/var:Y284C Tyr-284, CHEBI:29950 PMID:10788442 PR:000000913 hKCNQ2/var:A306T Ala-306, CHEBI:30013 PMID:10788442

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