| PRO ID |
PR:000000907
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/ PAF
|
| PRO name |
voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human) |
| Synonyms |
| PRO-short-label: |
hKCNQ2/var:S247W |
| EXACT: |
voltage-gated potassium channel subunit KCNQ2 sequence variant 1 (human) |
| PRO-proteoform-std: |
UniProtKB:O43526-1, Ser-247, CHEBI:29954 |
|
| Definition |
A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Trp residue at the position equivalent to Ser-247 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Ser-247, CHEBI:29954.
[PMID:12742592, PRO:CNA, PRO:DAN]
|
| Comment |
Note: This residue is located within the transmembrane S5. This form reduces the current amplitude of KCNQ2 homomeric channels in a dominant-negative manner whereas the amplitude of KCNQ2/KCNQ3 heteromers is only reduced by about 40%. |
| PRO Category |
organism-sequence |
| Parent |
PR:O43526 potassium voltage-gated channel subfamily KQT member 2 (human) |
| Term Hierarchy Visualization |
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