back to PRO homepage

Protein Ontology Report - hSMAD4

PR:Q13485 - http://purl.obolibrary.org/obo/PR_Q13485
This page represents a class of proteins encompassing all the protein products of the SMAD4 gene in human .
Ontology Information
PRO ID PR:Q13485 Show OBO stanza / PAF
PRO name smad4 (human)
Synonyms
PRO-short-label: hSMAD4
Definition A smad4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13485]
PRO Category organism-gene
Parent PR:000000128 smad4
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 6
organism-modification 5
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD4 forms found in complexes
hSMAD4 Component Complexes
PR:Q13485 hSMAD4 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:Q13485-1 hSMAD4/iso:1 PR:000025947 smad2-smad4 protein complex 4 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q13485-1
hSMAD4/iso:1
has_function GO:0003700 DNA-binding transcription factor activity PMID:10823886
has_function GO:0003712 transcription coregulator activity PMID:10980615
located_in GO:0005634 nucleus PMID:10980615, PMID:15280432
located_in GO:0005737 cytoplasm PMID:15280432
part_of GO:0005667 transcription factor complex PMID:12374795
participates_in GO:0030509 BMP signaling pathway PMID:14633973
participates_in GO:0007183 SMAD protein complex assembly PMID:10980615, PMID:15350224, PMID:9346966
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805, PMID:8774881
PR:000025958
hSMAD4/iso:1/MonoUbiq:2
Lys-519, MOD:01148
has_function NOT GO:0046332 SMAD binding PMID:19135894
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894
PR:000025946
smad2-smad4 protein complex 3 (human)
located_in GO:0005634 nucleus PMID:12193595
participates_in GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PMID:12193595
PR:000025947
smad2-smad4 protein complex 4 (human)
located_in GO:0005737 cytoplasm PMID:11027280
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:11027280
PR:000025952
smad2-smad4-ski protein complex 2 (human)
located_in GO:0005737 cytoplasm PMID:12732634
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:12732634
PR:000025951
smad2-smad4-ski protein complex 1 (human)
located_in GO:0005634 nucleus PMID:10485843
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:10485843
PR:000000368
hSMAD4/var:G352R
Gly-352, CHEBI:29952
associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513
associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:12417513
has_agent SO:0001606 amino_acid_substitution PMID:12417513
PR:000000367
hSMAD4/var:E330G
Glu-330, CHEBI:29947
associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513
has_agent SO:0001606 amino_acid_substitution PMID:12417513
PR:000036483
hSMAD4/iso:1/Phos:1
Thr-277, MOD:00047
has_function GO:0003700 DNA-binding transcription factor activity increased relative to PR:000002539 SMAD4/iso:1/UnMod PMID:12801888
located_in GO:0005634 nucleus PMID:12801888
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888
PR:000000370
hSMAD4/var:G386D
Gly-386, CHEBI:29958
associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:15031030
has_agent SO:0001606 amino_acid_substitution PMID:15031030
PR:000000371
hSMAD4/var:D493H
Asp-493, CHEBI:29979
associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:8553070
has_agent SO:0001606 amino_acid_substitution PMID:8553070
PR:000000369
hSMAD4/var:R361C
Arg-361, CHEBI:29950
associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:9811934
has_agent SO:0001606 amino_acid_substitution PMID:9811934
PR:000025933
smad2-smad4 protein complex 1 (human)
located_in GO:0005654 nucleoplasm Reactome:REACT_7382
located_in GO:0005829 cytosol Reactome:REACT_7344
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228
Molecular Function GO Term Protein Forms & Complexes Evidence
NOT GO:0046332 SMAD binding PR:000025958 hSMAD4/iso:1/MonoUbiq:2
Lys-519, MOD:01148
PMID:19135894
GO:0003712 transcription coregulator activity PR:Q13485-1 hSMAD4/iso:1

PMID:10980615
GO:0003700 DNA-binding transcription factor activity PR:000036483 hSMAD4/iso:1/Phos:1
Thr-277, MOD:00047
increased relative to PR:000002539 SMAD4/iso:1/UnMod
PMID:12801888
PR:Q13485-1 hSMAD4/iso:1

PMID:10823886
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PR:000025946 smad2-smad4 protein complex 3 (human)

PMID:12193595
GO:0030509 BMP signaling pathway PR:Q13485-1 hSMAD4/iso:1

PMID:14633973
GO:0007183 SMAD protein complex assembly PR:Q13485-1 hSMAD4/iso:1

PMID:10980615, PMID:15350224, PMID:9346966
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PR:000025947 smad2-smad4 protein complex 4 (human)

PMID:11027280
PR:000025951 smad2-smad4-ski protein complex 1 (human)

PMID:10485843
PR:000025952 smad2-smad4-ski protein complex 2 (human)

PMID:12732634
PR:000025958 hSMAD4/iso:1/MonoUbiq:2
Lys-519, MOD:01148
PMID:19135894
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000025933 smad2-smad4 protein complex 1 (human)

PMID:8752209, PMID:8980228
PR:000036483 hSMAD4/iso:1/Phos:1
Thr-277, MOD:00047
PMID:12801888
PR:Q13485-1 hSMAD4/iso:1

PMID:17142805, PMID:8774881
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7344
GO:0005654 nucleoplasm PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7382
GO:0005634 nucleus PR:000025946 smad2-smad4 protein complex 3 (human)

PMID:12193595
PR:000025951 smad2-smad4-ski protein complex 1 (human)

PMID:10485843
PR:000036483 hSMAD4/iso:1/Phos:1
Thr-277, MOD:00047
PMID:12801888
PR:Q13485-1 hSMAD4/iso:1

PMID:10980615, PMID:15280432
GO:0005737 cytoplasm PR:000025947 smad2-smad4 protein complex 4 (human)

PMID:11027280
PR:000025952 smad2-smad4-ski protein complex 2 (human)

PMID:12732634
PR:Q13485-1 hSMAD4/iso:1

PMID:15280432

top