Protein Ontology Report - hSMAD4 PR:Q13485 - http://purl.obolibrary.org/obo/PR_Q13485

This page represents a class of proteins encompassing all the protein products of the SMAD4 gene in human .

Ontology Information
PRO ID	PR:Q13485 Show OBO stanza / PAF
PRO name	mothers against decapentaplegic homolog 4 (human)
Synonyms	PRO-short-label: hSMAD4 EXACT: MAD homolog 4 (human); SMAD 4 (human); SMAD family member 4 (human); Smad4 (human); deletion target in pancreatic carcinoma 4 (human); mothers against DPP homolog 4 (human) Gene-based: DPC4; MADH4; SMAD4
Definition	A smad4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13485]
PRO Category	organism-gene
Parent	PR:000000128 smad4
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 6 organism-modification 5
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:6770, Reactome:R-HSA-170862, Reactome:R-HSA-177103, UniProtKB:Q13485

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD4 forms found in complexes

hSMAD4 Component Complexes PR:Q13485 hSMAD4 PR:000025933 smad2-smad4 protein complex 1 (human) PR:Q13485-1 hSMAD4/iso:1 PR:000025951 smad2-smad4-ski protein complex 1 (human) PR:Q13485-1 hSMAD4/iso:1 PR:000025946 smad2-smad4 protein complex 3 (human) PR:Q13485-1 hSMAD4/iso:1 PR:000025940 smad2-smad4 protein complex 2 (human) PR:Q13485-1 hSMAD4/iso:1 PR:000025952 smad2-smad4-ski protein complex 2 (human) PR:Q13485-1 hSMAD4/iso:1 PR:000025947 smad2-smad4 protein complex 4 (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:Q13485-1 hSMAD4/iso:1 capable_of GO:0003712 transcription coregulator activity PMID:10980615 capable_of GO:0003700 DNA-binding transcription factor activity PMID:10823886 located_in GO:0005634 nucleus PMID:10980615, PMID:15280432 located_in GO:0005737 cytoplasm PMID:15280432 part_of GO:0005667 transcription factor complex PMID:12374795 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805, PMID:8774881 participates_in GO:0007183 SMAD protein complex assembly PMID:10980615, PMID:15350224, PMID:9346966 participates_in GO:0030509 BMP signaling pathway PMID:14633973 PR:000025958 hSMAD4/iso:1/MonoUbiq:2 Lys-519, MOD:01148 capable_of NOT GO:0046332 SMAD binding PMID:19135894 participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894 PR:000025946 smad2-smad4 protein complex 3 (human) located_in GO:0005634 nucleus PMID:12193595 participates_in GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PMID:12193595 PR:000025947 smad2-smad4 protein complex 4 (human) located_in GO:0005737 cytoplasm PMID:11027280 participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:11027280 PR:000025952 smad2-smad4-ski protein complex 2 (human) located_in GO:0005737 cytoplasm PMID:12732634 participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:12732634 PR:000025951 smad2-smad4-ski protein complex 1 (human) located_in GO:0005634 nucleus PMID:10485843 participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:10485843 PR:000000368 hSMAD4/var:G352R Gly-352, CHEBI:29952 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513 associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:12417513 PR:000000367 hSMAD4/var:E330G Glu-330, CHEBI:29947 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513 PR:000036483 hSMAD4/iso:1/Phos:1 Thr-277, MOD:00047 capable_of GO:0003700 DNA-binding transcription factor activity increased relative to PR:000002539 SMAD4/iso:1/UnMod PMID:12801888 located_in GO:0005634 nucleus PMID:12801888 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888 PR:000000370 hSMAD4/var:G386D Gly-386, CHEBI:29958 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:15031030 PR:000000371 hSMAD4/var:D493H Asp-493, CHEBI:29979 associated_with_disease_progression DOID:4905 pancreatic carcinoma PMID:8553070 PR:000000369 hSMAD4/var:R361C Arg-361, CHEBI:29950 associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:9811934 PR:000025933 smad2-smad4 protein complex 1 (human) located_in GO:0005654 nucleoplasm Reactome:REACT_7382 located_in GO:0005829 cytosol Reactome:REACT_7344 participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228 Biological Process GO Term Protein Forms & Complexes Evidence GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PR:000025946 smad2-smad4 protein complex 3 (human) PMID:12193595 GO:0007183 SMAD protein complex assembly PR:Q13485-1 hSMAD4/iso:1 PMID:10980615, PMID:15350224, PMID:9346966 GO:0030509 BMP signaling pathway PR:Q13485-1 hSMAD4/iso:1 PMID:14633973 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PR:000025947 smad2-smad4 protein complex 4 (human) PMID:11027280 PR:000025951 smad2-smad4-ski protein complex 1 (human) PMID:10485843 PR:000025952 smad2-smad4-ski protein complex 2 (human) PMID:12732634 PR:000025958 hSMAD4/iso:1/MonoUbiq:2 Lys-519, MOD:01148 PMID:19135894 GO:0007179 transforming growth factor beta receptor signaling pathway PR:000025933 smad2-smad4 protein complex 1 (human) PMID:8752209, PMID:8980228 PR:000036483 hSMAD4/iso:1/Phos:1 Thr-277, MOD:00047 PMID:12801888 PR:Q13485-1 hSMAD4/iso:1 PMID:17142805, PMID:8774881 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005829 cytosol PR:000025933 smad2-smad4 protein complex 1 (human) Reactome:REACT_7344 GO:0005654 nucleoplasm PR:000025933 smad2-smad4 protein complex 1 (human) Reactome:REACT_7382 GO:0005634 nucleus PR:000025946 smad2-smad4 protein complex 3 (human) PMID:12193595 PR:000025951 smad2-smad4-ski protein complex 1 (human) PMID:10485843 PR:000036483 hSMAD4/iso:1/Phos:1 Thr-277, MOD:00047 PMID:12801888 PR:Q13485-1 hSMAD4/iso:1 PMID:10980615, PMID:15280432 GO:0005737 cytoplasm PR:000025947 smad2-smad4 protein complex 4 (human) PMID:11027280 PR:000025952 smad2-smad4-ski protein complex 2 (human) PMID:12732634 PR:Q13485-1 hSMAD4/iso:1 PMID:15280432

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